CAJ | 학술논문

活体成像技术可以在近无创条件下对活体组织或小动物体内的生物学行为进行成像跟踪，已被广泛应用于肿瘤研究中。它的优势在于非侵入性地连续动态检测活体内肿瘤的生长及转移和评价肿瘤治疗的疗效。与传统的检测方法相比，大大减少了动物的用量，符合“3R”原则。文中综述了小动物活体成像技术的成像模式、技术原理和路线及其在肿瘤生长、转移与治疗过程中的应用。
활체성상기술가이재근무창조건하대활체조직혹소동물체내적생물학행위진행성상근종，이피엄범응용우종류연구중。타적우세재우비침입성지련속동태검측활체내종류적생장급전이화평개종류치료적료효。여전통적검측방법상비，대대감소료동물적용량，부합“3R”원칙。문중종술료소동물활체성상기술적성상모식、기술원리화로선급기재종류생장、전이여치료과정중적응용。
In vivo imaging technology has been used to take images of biological behavior in the living tissues or small animals under the noninvasive conditions, which has been widely applied in caner research. It has great advantage of real-time in vivo detection of tumor growth, metastasis and evaluation of tumor therapy. Compared with the traditional detection methods, in vivo imaging greatly reduces the number of test animals, which is consistent with the principle of“3R”. This paper reviews the imaging modes, technical principles and routes, and the applications of in vivo imaging technology in the field of tumor growth, metastasis and treatment process of small animals.