CAJ | 학술논문

以对硝基苯甲酸乙酯为原料， Pd/C为催化剂，甲酸铵为供氢体，乙醇为溶剂，对在室温下反应得到对氨基苯甲酸乙酯的催化转移氢化反应进行了研究。在相同的催化体系下，本佐卡因的类似物也得以高效合成。该催化转移氢化反应除温和的反应条件和高催化活性外，还兼具良好的放大前景。
이대초기분갑산을지위원료， Pd/C위최화제，갑산안위공경체，을순위용제，대재실온하반응득도대안기분갑산을지적최화전이경화반응진행료연구。재상동적최화체계하，본좌잡인적유사물야득이고효합성。해최화전이경화반응제온화적반응조건화고최화활성외，환겸구량호적방대전경。
The catalytic transfer hydrogenation of ethyl p-nitrobenzoate to ethyl 4-aminobenzoate is studied at room temperature with ammonium format as the hydrogen donor and ethanol as the solvent using Pd/C as catalyst. Under the same catalytic condition, the analogs of benzocaine is also synthesized in high yields. The present catalytic transfer hydrogenation reaction can be made under mild reactions conditions with high catalytic reactivity and also shows a great scale-up prospect.