CAJ | 학술논문

目的利用DTI探讨急性酒精中毒对大鼠脑干弥漫性轴索损伤(DAI)的影响。材料与方法85只雄性大鼠，分对照组(N组)，急性酒精中毒组(A组)，DAI组(T组)和急性酒精中毒合并DAI组(AT组)。对照组和各实验组动物(模型制作成功后1 h、3 h、6 h、12 h、24 h)进行MRI检查，并取脑干进行病理学检查。结果急性酒精中毒合并DAI组脑干ADC值于伤后1 h开始降低，6 h达最低点，此后ADC值逐渐升高，24 h达到最高；FA值1 h即降低，随时间逐渐降低，24 h达到最低值。急性酒精中毒合并DAI组伤后各时间点FA值低于单纯DAI组，伤后3 h、6 h差异有统计学意义；12 h内ADC值低于单纯DAI组，24 h后高于DAI组。结论急性酒精中毒可以加重DAI后脑水肿及轴索损伤，DTI能更敏感地检测到常规MRI不能发现的急性酒精中毒合并DAI后脑干部位脑水肿及轴索损伤情况。
목적이용DTI탐토급성주정중독대대서뇌간미만성축색손상(DAI)적영향。재료여방법85지웅성대서，분대조조(N조)，급성주정중독조(A조)，DAI조(T조)화급성주정중독합병DAI조(AT조)。대조조화각실험조동물(모형제작성공후1 h、3 h、6 h、12 h、24 h)진행MRI검사，병취뇌간진행병이학검사。결과급성주정중독합병DAI조뇌간ADC치우상후1 h개시강저，6 h체최저점，차후ADC치축점승고，24 h체도최고；FA치1 h즉강저，수시간축점강저，24 h체도최저치。급성주정중독합병DAI조상후각시간점FA치저우단순DAI조，상후3 h、6 h차이유통계학의의；12 h내ADC치저우단순DAI조，24 h후고우DAI조。결론급성주정중독가이가중DAI후뇌수종급축색손상，DTI능경민감지검측도상규MRI불능발현적급성주정중독합병DAI후뇌간부위뇌수종급축색손상정황。
Objective:To assess the effects of alcohol on traumatic brain injury (TBI) by using diffusion tensor imaging (DTI) in rat brainstems following acute alcohol intoxication with diffuse axonal injury (DAI). Materials and Methods:85 male rats, divided into control group (group N), acute alcohol poisoning group (group A), DAI Group (group T) and ethanol-plus-DAI group (group AT). The control group and the experimental group (made into animal model after 1 h, 3 h, 6 h, 12 h, 24 h) were examined by MRI, and the brainstem pathology. Results:After acute alcoholism with DAI, ADC values of the brainstem first decreased within 6 h after injury and then elevated. FA values began decline by 1 h, reaching a minimum at 24 h after trauma. FA values were lower in the ethanol-plus-DAI group (group AT) compared to the DAI group (group T) at 3 h and 6 h. The ADC value of the ethanol-plus-DAI group (group AT) is lower than the DAI group (group T) in 12 h, but it is higher after 24 h. Conclusions:Acute ethanol consumption affects severity after DAI by accelerating brain edema and axonal injury. DTI can sensitively to detect acute alcohol intoxication with TBI in brainstem edema and axonal, while the routin MRI cannot found.