上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
9期
8-10
,共3页
侵袭性真菌感染%经验性治疗%抢先治疗
侵襲性真菌感染%經驗性治療%搶先治療
침습성진균감염%경험성치료%창선치료
invasive fungal infection%empirical therapy%preemptive antifungal therapy
侵袭性真菌感染（invasive fungal infection, IFI）更趋常见，其原因除广谱抗生素的应用以及肿瘤放疗和化疗、造血干细胞移植、器官移植和免疫功能缺陷患者增多等外，最主要的是新的诊断真菌感染的临床实验室技术、尤其是半乳甘露聚糖试验和(1,3)-β-D-葡聚糖试验的应用逐渐普及，为临床诊断IFI提供了坚实的基础。此外，IFI的影像学特征也成为诊断IFI的一个重要条件。与经验性抗真菌治疗相比，这些实验室和影像学检查的阳性结果可提高诊断的可靠性，由此为真菌感染治疗提供更多的依据，同时减少抗真菌药物的滥用。
侵襲性真菌感染（invasive fungal infection, IFI）更趨常見，其原因除廣譜抗生素的應用以及腫瘤放療和化療、造血榦細胞移植、器官移植和免疫功能缺陷患者增多等外，最主要的是新的診斷真菌感染的臨床實驗室技術、尤其是半乳甘露聚糖試驗和(1,3)-β-D-葡聚糖試驗的應用逐漸普及，為臨床診斷IFI提供瞭堅實的基礎。此外，IFI的影像學特徵也成為診斷IFI的一箇重要條件。與經驗性抗真菌治療相比，這些實驗室和影像學檢查的暘性結果可提高診斷的可靠性，由此為真菌感染治療提供更多的依據，同時減少抗真菌藥物的濫用。
침습성진균감염（invasive fungal infection, IFI）경추상견，기원인제엄보항생소적응용이급종류방료화화료、조혈간세포이식、기관이식화면역공능결함환자증다등외，최주요적시신적진단진균감염적림상실험실기술、우기시반유감로취당시험화(1,3)-β-D-포취당시험적응용축점보급，위림상진단IFI제공료견실적기출。차외，IFI적영상학특정야성위진단IFI적일개중요조건。여경험성항진균치료상비，저사실험실화영상학검사적양성결과가제고진단적가고성，유차위진균감염치료제공경다적의거，동시감소항진균약물적람용。
Due to the use of broad-spectrum antibiotics and the increasing number of the immune-incompetent patients who received tumor radiotherapy and chemotherapy, hematopoietic stem cell transplantation, organ transplantation as well as immunosuppressive therapy, the incidence of invasive fungal infection (IFI) has been gradually increased. Another more important cause was the improvement of the laboratory and imaging diagnosis technology, especially (1,3)-β-D-glucan test and galactomannan test, which provide solid basis for clinical diagnosis of IFI so as to increase the diagnostic rate. Compared with empirical anti-fungal therapy, these positive results from the laboratory assay and imaging examination can increase the reliability of the diagnosis of IFI and provide more evidence for the treatment of IFI, and meanwhile reduce the abuse of antifungal agents.
