CAJ | 학술논문

膜内成骨是骨骼形成的重要方式，其受多条信号通路的调控，Notch信号通路是其中重要的一条。异常的Notch信号通路影响骨骼的形成。深入探讨Notch信号通路在膜内成骨中的作用机制，有利于揭示临床多种骨骼畸形，尤其是颅颌面骨发育异常的发生机制，提供新的治疗靶标。本文概述Notch信号通路对膜内成骨过程的调控。
막내성골시골격형성적중요방식，기수다조신호통로적조공，Notch신호통로시기중중요적일조。이상적Notch신호통로영향골격적형성。심입탐토Notch신호통로재막내성골중적작용궤제，유리우게시림상다충골격기형，우기시로합면골발육이상적발생궤제，제공신적치료파표。본문개술Notch신호통로대막내성골과정적조공。
Intramembranous ossification is regulated and affected by many signal pathways. Notch signaling pathway plays important roles in bone formation. Abnormal Notch signaling pathway leads to the bone deformities. Understanding the function of Notch signaling pathway in osteogenesis reveals mechanisms of various bone deformities,especially crani-omaxillofacial bone deformities. This article focuses on functions of Notch signaling pathway and its regulation on osteo-genesis.