CAJ | 학술논문

目的观察普罗布考联合阿托伐他汀对老年高血压病合并颈动脉粥样硬化的影响。方法将60例高血压病合并颈动脉内膜中层厚度（ IMT）增厚和（或）颈动脉粥样硬化斑块患者，按入院就诊单双号分成普罗布考治疗组、普罗布考联合阿托伐他汀治疗组（联合组）各30例，疗程6个月。观察两组治疗前后颈动脉IMT厚度及颈动脉粥样硬化斑块面积变化及血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、氧化型低密度脂蛋白（ ox-LDL）和高敏C反应蛋白（ hs-CRP）水平的变化。结果治疗后两组颈动脉IMT、颈动脉内膜斑块面积均减小（P＜0．05），而且联合组颈动脉IMT、颈动脉内膜斑块面积减少更为显著（P＜0．01）。两组治疗后TC、TG、LDL-C、ox-LDL、hs-CRP比治疗前均明显下降，并且联合组上述指标明显低于普罗布考组（ P均＜0．01）。结论普罗布考联合阿托伐他汀治疗老年高血压病合并颈动脉IMT增厚及粥样硬化斑块有显著疗效，无明显不良反应。
목적관찰보라포고연합아탁벌타정대노년고혈압병합병경동맥죽양경화적영향。방법장60례고혈압병합병경동맥내막중층후도（ IMT）증후화（혹）경동맥죽양경화반괴환자，안입원취진단쌍호분성보라포고치료조、보라포고연합아탁벌타정치료조（연합조）각30례，료정6개월。관찰량조치료전후경동맥IMT후도급경동맥죽양경화반괴면적변화급혈청총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL-C）、양화형저밀도지단백（ ox-LDL）화고민C반응단백（ hs-CRP）수평적변화。결과치료후량조경동맥IMT、경동맥내막반괴면적균감소（P＜0．05），이차연합조경동맥IMT、경동맥내막반괴면적감소경위현저（P＜0．01）。량조치료후TC、TG、LDL-C、ox-LDL、hs-CRP비치료전균명현하강，병차연합조상술지표명현저우보라포고조（ P균＜0．01）。결론보라포고연합아탁벌타정치료노년고혈압병합병경동맥IMT증후급죽양경화반괴유현저료효，무명현불량반응。
Objective To observe the effect of probucol combined with atorvastatin on elderly hypertension patients with carotid atherosclerosis .Methods Sixty hypertension patients with thicken carotid intima-media thick-ness( IMT) and/or carotid atherosclerosis plaque were randomly divided into probucol group and probucol plus atorv -astatin group ( combination group ) according to their admission numbers ,30 cases in each group .The treatment lasted for six months .The changes of carotid IMT and carotid atheiosclerosis plaque area ,and levels of serum total cholester-ol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),oxidized low density lipoprotein(ox-LDL) and high-sensitivity C-reactive protein( hs-CRP) were detected in both groups before and after treatment .Results Carot-id IMT and plaque areas decreased significantly in both group after treatment (P<0.05),the decrease in the combina-tion group was more significant (P<0.01).TC,TG,LDL-C,ox-LDL and hs-CRP decreased significantly after treat-ment in both groups compared with those before treatment ,and the indices above in the combination group were signifi-cantly lower than those in the probucol group ( all P<0.01).Conclusion The therapy of probucol plus atorvastatin for the treatment of elderly hypertension patients with thicken carotid IMT and atherosclerosis plaque has significant effect without significant adverse reactions .