风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2013年
8期
27-30
,共4页
方斌%刘文刚%赵自明%许学猛%魏凌峰%赵传喜%谢国平%鲁海%刘欣
方斌%劉文剛%趙自明%許學猛%魏凌峰%趙傳喜%謝國平%魯海%劉訢
방빈%류문강%조자명%허학맹%위릉봉%조전희%사국평%로해%류흔
骨关节炎,膝%参麦注射液%关节内注射治疗%实验研究%家兔
骨關節炎,膝%參麥註射液%關節內註射治療%實驗研究%傢兔
골관절염,슬%삼맥주사액%관절내주사치료%실험연구%가토
osteoarthritis,knee%shenmai injection%the treatment of intraarticular injection%rabbit%experimental study
目的:观察关节内注射参麦注射液治疗家兔膝骨关节炎的疗效。方法:以40只健康SPF级新西兰家兔为研究对象,随机分为正常对照组、模型组、参麦注射液组(以下称参麦组)、利多卡因组和参麦注射液+利多卡因组(以下称参麦+利多组)5组,每组8只,除正常对照组外,其余4组采用木瓜蛋白酶所致兔膝骨关节炎模型。正常对照组、模型组分别予关节内注射0.4mL的注射用生理盐水,参麦组注射0.4mL参麦注射液,利多卡因组注射0.4mL利多卡因,参麦+利多组注射二者混合液0.4mL,每周1次,连续8次,观察家兔步态、膝关节周径及关节液中炎症因子浓度。结果:造模后2周家兔步态除正常对照组外,其余4组造模前后步态均有明显变化(P=0.018<0.05),参麦组与参麦+利多组给药4次后步态与造模前无明显差异(P=0.021、0.012<0.05);给药8次后膝关节周径变化与正常对照组比较,模型组膝关节周长增大,差异有统计学意义(P=0.0049<0.05),参麦组有所增大,差异无统计学意义(P=0.13>0.05),利多卡因组明显增大,差异有统计学意义(P=0.029<0.05),参麦+利多组减小,但差异无统计学意义(P=0.77>0.05);局部炎症因子水平结果与正常对照组比较,模型组IL-1β、IL-6、TNF-α水平均升高,差异有统计学意义(P=0.023,0.001,0.014<0.05),参麦组有所升高,差异无统计学意义(P=0.061,0.13,0.527>0.05),利多卡因组明显升高,差异有统计学意义(P=0.031,0.008,0.025<0.05),参麦+利多组有所升高,但差异无统计学意义(P=0.087,0.17,0.18>0.05)。结论:关节内注射参麦注射液能明显改善模型兔步态,消除膝关节肿胀,同时可以降低关节液的炎症因子如IL-1β、IL-6、TNF-α水平。
目的:觀察關節內註射參麥註射液治療傢兔膝骨關節炎的療效。方法:以40隻健康SPF級新西蘭傢兔為研究對象,隨機分為正常對照組、模型組、參麥註射液組(以下稱參麥組)、利多卡因組和參麥註射液+利多卡因組(以下稱參麥+利多組)5組,每組8隻,除正常對照組外,其餘4組採用木瓜蛋白酶所緻兔膝骨關節炎模型。正常對照組、模型組分彆予關節內註射0.4mL的註射用生理鹽水,參麥組註射0.4mL參麥註射液,利多卡因組註射0.4mL利多卡因,參麥+利多組註射二者混閤液0.4mL,每週1次,連續8次,觀察傢兔步態、膝關節週徑及關節液中炎癥因子濃度。結果:造模後2週傢兔步態除正常對照組外,其餘4組造模前後步態均有明顯變化(P=0.018<0.05),參麥組與參麥+利多組給藥4次後步態與造模前無明顯差異(P=0.021、0.012<0.05);給藥8次後膝關節週徑變化與正常對照組比較,模型組膝關節週長增大,差異有統計學意義(P=0.0049<0.05),參麥組有所增大,差異無統計學意義(P=0.13>0.05),利多卡因組明顯增大,差異有統計學意義(P=0.029<0.05),參麥+利多組減小,但差異無統計學意義(P=0.77>0.05);跼部炎癥因子水平結果與正常對照組比較,模型組IL-1β、IL-6、TNF-α水平均升高,差異有統計學意義(P=0.023,0.001,0.014<0.05),參麥組有所升高,差異無統計學意義(P=0.061,0.13,0.527>0.05),利多卡因組明顯升高,差異有統計學意義(P=0.031,0.008,0.025<0.05),參麥+利多組有所升高,但差異無統計學意義(P=0.087,0.17,0.18>0.05)。結論:關節內註射參麥註射液能明顯改善模型兔步態,消除膝關節腫脹,同時可以降低關節液的炎癥因子如IL-1β、IL-6、TNF-α水平。
목적:관찰관절내주사삼맥주사액치료가토슬골관절염적료효。방법:이40지건강SPF급신서란가토위연구대상,수궤분위정상대조조、모형조、삼맥주사액조(이하칭삼맥조)、리다잡인조화삼맥주사액+리다잡인조(이하칭삼맥+리다조)5조,매조8지,제정상대조조외,기여4조채용목과단백매소치토슬골관절염모형。정상대조조、모형조분별여관절내주사0.4mL적주사용생리염수,삼맥조주사0.4mL삼맥주사액,리다잡인조주사0.4mL리다잡인,삼맥+리다조주사이자혼합액0.4mL,매주1차,련속8차,관찰가토보태、슬관절주경급관절액중염증인자농도。결과:조모후2주가토보태제정상대조조외,기여4조조모전후보태균유명현변화(P=0.018<0.05),삼맥조여삼맥+리다조급약4차후보태여조모전무명현차이(P=0.021、0.012<0.05);급약8차후슬관절주경변화여정상대조조비교,모형조슬관절주장증대,차이유통계학의의(P=0.0049<0.05),삼맥조유소증대,차이무통계학의의(P=0.13>0.05),리다잡인조명현증대,차이유통계학의의(P=0.029<0.05),삼맥+리다조감소,단차이무통계학의의(P=0.77>0.05);국부염증인자수평결과여정상대조조비교,모형조IL-1β、IL-6、TNF-α수평균승고,차이유통계학의의(P=0.023,0.001,0.014<0.05),삼맥조유소승고,차이무통계학의의(P=0.061,0.13,0.527>0.05),리다잡인조명현승고,차이유통계학의의(P=0.031,0.008,0.025<0.05),삼맥+리다조유소승고,단차이무통계학의의(P=0.087,0.17,0.18>0.05)。결론:관절내주사삼맥주사액능명현개선모형토보태,소제슬관절종창,동시가이강저관절액적염증인자여IL-1β、IL-6、TNF-α수평。
Objective:To evaluate the safety and efficacy of intra articular injection of shenmai injection in treating knee osteoarthritis.Methods:40 healthy SPF new zealand rabbits were induced into the knee-osteoarthritis models by papain and randomly and equally divided into 5 groups:the normal group,the model group,the shenmai injection group(the shenmai group),the lidocaine group and the shenmai injection and lidocaine group(the shenmai + droperidol group).The normal group and the model groups were given intra-articular injection of normal saline(0.4 mL),the Shenmai group were given injection of Shenmai of shenmai and droperidol(0.4 mL),1 time a week for 8 weeks for above groups,observing their gait,the knee circumference and the inflammation factor concentration in the synovial fluid.Results:2 weeks after modeling,the rabbit gait but that of the normal group changed obviously(P= 0.018<0.05).The gait of the shenmai injection group and the shenmai+droperidol group had no obvious change after 4 times of administration than that before modeling(P=0.021,0.012<0.05).The knee circumference of the model group enlarged after 8 times of administration compared with the normal group,the difference being statistically significant(P=0.0049<0.05),that of the shenmai group also enlarged,having no significant difference(P=0.13>0.05),that of the lidocaine group increased obviously,the difference being statistically significant(P=0.029<0.05),but that of the shenmai+droperidol group decreased,the difference being not statistically significant(P=0.77>0.05). As for the local inlfammatory factor levels compared with the normal group,IL-1 β,IL-6,TNF-α levels of the model group increased,the difference being statistically signiifcant(P=0.023,0.001,0.014<0.05),of the shenmai group a little increased,without significant difference(P=0.061,0.13,0.527>0.05),of the lidocaine group increased significantly,the difference being statistically significant(P=0.031,0.008,0.025<0.05),and of the shenmai+droperidol group increased,but the difference being not statistically significant(P=0.087,0.17,0.18>0.05). Conclusion:Intra articular injection of shenmai injection could obviously improve the gait of rabbit model,eliminate the knee joint swelling,and reduce the level of inlfammatory factors in the synovial lfuid such as IL-1β,IL-6 and TNF-α.