风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2013年
8期
5-8
,共4页
陈洁君%吉恒东%郭士成%王一%李媛%金力%王久存%宋新强
陳潔君%吉恆東%郭士成%王一%李媛%金力%王久存%宋新彊
진길군%길항동%곽사성%왕일%리원%금력%왕구존%송신강
关节炎,类风湿%HLA-DQAl%拷贝数目多态性%易感性%中国汉族人
關節炎,類風濕%HLA-DQAl%拷貝數目多態性%易感性%中國漢族人
관절염,류풍습%HLA-DQAl%고패수목다태성%역감성%중국한족인
arthritis,rheumatoid%HLA-DQA1%copy number polymorphisms%susceptibility%treatment%Chinese Han population
目的：探讨中国汉族人群中HLA-DQAl基因拷贝数目多态性与类风湿关节炎发病风险的关系。方法：采用比较基因组杂交和AccuCopy检测技术，检测138例类风湿关节炎患者和191例正常对照者的HLA-DQAl基因拷贝数目。采用Logistic回归模型分析各基因型患者类风湿关节炎的发病风险。结果：HLA-DQAl基因拷贝数目增加的个体，类风湿关节炎发病风险显著升高（P=0.009）。结论：HLA-DQAl基因拷贝数目多态是RA的遗传易感因素，HLA-DQAl基因拷贝数目增加则是类风湿关节炎的危险因素。
目的：探討中國漢族人群中HLA-DQAl基因拷貝數目多態性與類風濕關節炎髮病風險的關繫。方法：採用比較基因組雜交和AccuCopy檢測技術，檢測138例類風濕關節炎患者和191例正常對照者的HLA-DQAl基因拷貝數目。採用Logistic迴歸模型分析各基因型患者類風濕關節炎的髮病風險。結果：HLA-DQAl基因拷貝數目增加的箇體，類風濕關節炎髮病風險顯著升高（P=0.009）。結論：HLA-DQAl基因拷貝數目多態是RA的遺傳易感因素，HLA-DQAl基因拷貝數目增加則是類風濕關節炎的危險因素。
목적：탐토중국한족인군중HLA-DQAl기인고패수목다태성여류풍습관절염발병풍험적관계。방법：채용비교기인조잡교화AccuCopy검측기술，검측138례류풍습관절염환자화191례정상대조자적HLA-DQAl기인고패수목。채용Logistic회귀모형분석각기인형환자류풍습관절염적발병풍험。결과：HLA-DQAl기인고패수목증가적개체，류풍습관절염발병풍험현저승고（P=0.009）。결론：HLA-DQAl기인고패수목다태시RA적유전역감인소，HLA-DQAl기인고패수목증가칙시류풍습관절염적위험인소。
Objective:To explore the association between the polymorphisms of HLA-DQA1 gene copy number and the onset risk of rheumatoid arthritis in Chinese Han population.Methods:The HLA-DQA1 gene copy numbers of 138 patients with rheumatoid arthritis and 191 controls were detected by comparative genomic hybridization(CGH)and AccuCopy assay.Logistic regression model was used to evaluate the impact of this polymorphism on the risk of pathogenesis of rheumatoid arthritis.Results:Carriers with larger number of HLA-DQA1 gene duplication had a signiifcantly increasing risk of rheumatoid arthritis(P=0.009).Conclusion:The polymorphism of HLA-DQA1 gene copy number was the predisposing factor of heredity and the increasing number of HLA-DQA1 gene duplication was a risk factor for rheumatoid arthritis.
