浙江中西医结合杂志
浙江中西醫結閤雜誌
절강중서의결합잡지
ZHEJIANG JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2013年
9期
700-702
,共3页
韩冰%应茵%丁晓霁%孙云峰%王晖
韓冰%應茵%丁曉霽%孫雲峰%王暉
한빙%응인%정효제%손운봉%왕휘
大鼠%肺心病%肺动脉高压%艾叶油
大鼠%肺心病%肺動脈高壓%艾葉油
대서%폐심병%폐동맥고압%애협유
rats pulmonary%heart disease%pulmonary arterial hypertension%Chinese mugwort leaf oil
目的：观察艾叶油对肺心病模型大鼠肺动脉高压的影响。方法：40只SD大鼠随机分为正常对照组、模型组和艾叶油高、低剂量组，每组10只。采用野百合碱（60mg/kg）腹腔注射建立大鼠肺心病模型，造模后正常对照组、模型组每天给予生理盐水灌胃，艾叶油高、低剂量组给于艾叶油混悬液（1.8、0.2g/kg）灌胃，连续21天。采用右心导管法测定平均右心室压（mRVP）、平均肺动脉压（mPAP）和最大肺动脉压力（Max mPAP），处死动物测定称取肺湿重（wW）、右心室游离壁（RV）、左心室加心室间隔（LV+S）质量，计算肺指数（LI）和右心肥厚指数（RVHI）。结果：模型组大鼠mRVP、mPAP和Max mPAP显著高于正常对照组（P<0.05或P<0.01），艾叶油低、高剂量组大鼠mPAP、mRVP和Max mRVP均显著低于模型组（P<0.05或P<0.01）；模型组大鼠RV、LV+S、wW、RVHI及LI均显著大于正常对照组（P均<0.01）；艾叶油高剂量组大鼠wW、RVHI显著低于模型组（P<0.05）。结论：艾叶油对野百合碱诱导的大鼠肺心病肺动脉高压有一定的干预作用。
目的：觀察艾葉油對肺心病模型大鼠肺動脈高壓的影響。方法：40隻SD大鼠隨機分為正常對照組、模型組和艾葉油高、低劑量組，每組10隻。採用野百閤堿（60mg/kg）腹腔註射建立大鼠肺心病模型，造模後正常對照組、模型組每天給予生理鹽水灌胃，艾葉油高、低劑量組給于艾葉油混懸液（1.8、0.2g/kg）灌胃，連續21天。採用右心導管法測定平均右心室壓（mRVP）、平均肺動脈壓（mPAP）和最大肺動脈壓力（Max mPAP），處死動物測定稱取肺濕重（wW）、右心室遊離壁（RV）、左心室加心室間隔（LV+S）質量，計算肺指數（LI）和右心肥厚指數（RVHI）。結果：模型組大鼠mRVP、mPAP和Max mPAP顯著高于正常對照組（P<0.05或P<0.01），艾葉油低、高劑量組大鼠mPAP、mRVP和Max mRVP均顯著低于模型組（P<0.05或P<0.01）；模型組大鼠RV、LV+S、wW、RVHI及LI均顯著大于正常對照組（P均<0.01）；艾葉油高劑量組大鼠wW、RVHI顯著低于模型組（P<0.05）。結論：艾葉油對野百閤堿誘導的大鼠肺心病肺動脈高壓有一定的榦預作用。
목적：관찰애협유대폐심병모형대서폐동맥고압적영향。방법：40지SD대서수궤분위정상대조조、모형조화애협유고、저제량조，매조10지。채용야백합감（60mg/kg）복강주사건립대서폐심병모형，조모후정상대조조、모형조매천급여생리염수관위，애협유고、저제량조급우애협유혼현액（1.8、0.2g/kg）관위，련속21천。채용우심도관법측정평균우심실압（mRVP）、평균폐동맥압（mPAP）화최대폐동맥압력（Max mPAP），처사동물측정칭취폐습중（wW）、우심실유리벽（RV）、좌심실가심실간격（LV+S）질량，계산폐지수（LI）화우심비후지수（RVHI）。결과：모형조대서mRVP、mPAP화Max mPAP현저고우정상대조조（P<0.05혹P<0.01），애협유저、고제량조대서mPAP、mRVP화Max mRVP균현저저우모형조（P<0.05혹P<0.01）；모형조대서RV、LV+S、wW、RVHI급LI균현저대우정상대조조（P균<0.01）；애협유고제량조대서wW、RVHI현저저우모형조（P<0.05）。결론：애협유대야백합감유도적대서폐심병폐동맥고압유일정적간예작용。
Objective:To observe the effect of Chinese mugwort leaf oil on pulmonary arterial hypertension in rats with pulmonary heart disease. Methods:Forty SD rats were randomly divided into control,model,and low-dose and high-dose drug groups,10 rats in each group. The animal model was established by intraperitoneally injecting monocrotaline of 60 mg/kg in the model and drug groups. Rats in the control and model groups were given saline by gavage for 21 days. The low- and high-dose groups were administered with Chinese mugwort leaf oil suspension in the same way in the same period as the above described. The mean right ventricular pressure(mRVP),mean pulmonary arterial pressure (mPAP),and max mPAP were measured by using right cardiac catheterization. The rats were then sacrificed for determination of lung wet weight (wW) and the weight of right ventricule (RV) and left ventricule plus septum (LV+S). Lung index and right ventricular hypertrophy index were calculated. Results:The mRVP,mPAP,max mPAP in the model group were higher than those of the control group (P<0.05 or P<0.01),and those parameters in the low- and high-dose drug groups were lower than those of the model group (P<0.05 or P<0.01). The RV,LV+S,wW,RVHI,and LI in the model group were larger than those of the control group (P<0.01), and the wW and RVHI in the high-dose drug group were smaller than those of the model group (P<0.05). Con-clusion:Chinese mugwort leaf oil may have some effect on pulmonary arterial hypertension induced by monocro-taline in rats.
