实用中医药杂志
實用中醫藥雜誌
실용중의약잡지
JOURNAL OF PRACTICAL TRADITIONAL CHINESE MEDICINE
2013年
9期
706-706,707
,共2页
青蒿琥酯%抗肿瘤作用%小鼠
青蒿琥酯%抗腫瘤作用%小鼠
청호호지%항종류작용%소서
Artesunate%Anti-tumor effect%Mouse
目的:探讨青蒿琥酯(artesunate,Art)的体内抗肿瘤活性。方法:接种S180肉瘤的小鼠随机分为模型组、5-氟尿嘧啶组(20mg/kg)、Art组(20mg/kg),每组10只,腹腔注射给药10天后,各组称体质量,计算抑瘤率、脾指数、胸腺指数。结果:Art组的瘤质量与模型组相比明显降低(P<0.01),抑瘤率达到43%。Art可提高脾指数和胸腺指数,对S180肉瘤所致的免疫器官功能低下有一定保护作用。结论:Art具备较好的体内抗肿瘤活性。
目的:探討青蒿琥酯(artesunate,Art)的體內抗腫瘤活性。方法:接種S180肉瘤的小鼠隨機分為模型組、5-氟尿嘧啶組(20mg/kg)、Art組(20mg/kg),每組10隻,腹腔註射給藥10天後,各組稱體質量,計算抑瘤率、脾指數、胸腺指數。結果:Art組的瘤質量與模型組相比明顯降低(P<0.01),抑瘤率達到43%。Art可提高脾指數和胸腺指數,對S180肉瘤所緻的免疫器官功能低下有一定保護作用。結論:Art具備較好的體內抗腫瘤活性。
목적:탐토청호호지(artesunate,Art)적체내항종류활성。방법:접충S180육류적소서수궤분위모형조、5-불뇨밀정조(20mg/kg)、Art조(20mg/kg),매조10지,복강주사급약10천후,각조칭체질량,계산억류솔、비지수、흉선지수。결과:Art조적류질량여모형조상비명현강저(P<0.01),억류솔체도43%。Art가제고비지수화흉선지수,대S180육류소치적면역기관공능저하유일정보호작용。결론:Art구비교호적체내항종류활성。
Objective:To investigate the anti-tumor activity of artesunate (Art) in vivo.Methods:Mice were transplanted with tumor S180,then divided into 3 groups at random,namely Art group (20mg/kg),5-Fu group (20mg/kg) and model group (n=10).All mice were intraperitoneally injected for ten days.After weighed,the effect of Art on tumor growth,spleen index or thymus index was determined.Results:Administration of Art improved weight and tumor growth in mice with transplanted tumor S180,compared to the model group (P<0.01).The S180 inhibition rate in Art group reached 43%. In addition,Art had a protective effect on immune suppression caused by tumor S180.Conclusion:Art could inhibit tumor growth effectively in vivo..