CAJ | 학술논문

目的探讨肽基脯氨酰顺反异构酶（peptidyl prolyl cis-trans isomerase，Pin1）蛋白在子宫内膜癌组织中的表达与临床病理特征的关系，及其与病程相关蛋白的（PR）表达的相关性。方法回顾性分析湘雅医院2010年2月~2012年10月收治50例子宫内膜癌临床病理资料，采用免疫组织化学方法对子宫内膜癌组织中pin1及PR蛋白的表达进行检测，结果采用卡方检验及Spearman相关系数法进行统计学分析。结果 pin1蛋白在子宫内膜癌中的阳性表达率为66%（33/50），其表达阳性率随着病理分化程度由高到低依次递减（高分化组93.3%，中分化组84.6%，低分化组36.4%），浅肌层浸润组pin1阳性表达率（77.4%）显著高于深肌层浸润组（47.4%），淋巴结转移组pin1阳性表达率（28.6%）显著低于淋巴结未转移组（72.1%）。pin1与PR阳性表达呈现正相关（P<0.05）。结论 pin1蛋白表达增高可能与子宫内膜癌的病理分化程度、肌层浸润深度及淋巴结转移有关，有望与PR一起成为预测子宫内膜癌患者治疗效果的一个重要的指标。
목적탐토태기포안선순반이구매（peptidyl prolyl cis-trans isomerase，Pin1）단백재자궁내막암조직중적표체여림상병리특정적관계，급기여병정상관단백적（PR）표체적상관성。방법회고성분석상아의원2010년2월~2012년10월수치50례자궁내막암림상병리자료，채용면역조직화학방법대자궁내막암조직중pin1급PR단백적표체진행검측，결과채용잡방검험급Spearman상관계수법진행통계학분석。결과 pin1단백재자궁내막암중적양성표체솔위66%（33/50），기표체양성솔수착병리분화정도유고도저의차체감（고분화조93.3%，중분화조84.6%，저분화조36.4%），천기층침윤조pin1양성표체솔（77.4%）현저고우심기층침윤조（47.4%），림파결전이조pin1양성표체솔（28.6%）현저저우림파결미전이조（72.1%）。pin1여PR양성표체정현정상관（P<0.05）。결론 pin1단백표체증고가능여자궁내막암적병리분화정도、기층침윤심도급림파결전이유관，유망여PR일기성위예측자궁내막암환자치료효과적일개중요적지표。
Objective To inverstigate the clinicopathologic significance of pin1 and PR in patients with endometrial adenocarcinoma. Methods The expression of pin1 and PR were investigated by immunohistochemistry in a total of 50 endometrial adenocarcinoma specimens. Results Pin1 was over expressed in 66%(33/50) of the cases. The expression rate decreased gradually with tumor differentiation(P<0.05). In addition, pin1 expression was negatively correlated with lymph node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression. Conclusion Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.