南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2013年
9期
1372-1376
,共5页
李云飞%刘海涛%都兴华%赖彩永%苏泽轩%高双全
李雲飛%劉海濤%都興華%賴綵永%囌澤軒%高雙全
리운비%류해도%도흥화%뢰채영%소택헌%고쌍전
膀胱尿路上皮癌%EN2%β-catenin
膀胱尿路上皮癌%EN2%β-catenin
방광뇨로상피암%EN2%β-catenin
bladder urothelial carcinoma%Engrailed-2%β-catenin
目的探讨膀胱尿路上皮癌中EN2与β-catenin的表达及其意义。方法选取60例手术切除的不同病理分级和分期的膀胱尿路上皮癌组织和10例正常膀胱粘膜组织。通过免疫组织化学、Western blot及RT-PCR方法分别检测EN2与β-catenin蛋白和基因的表达情况。结果 EN2及β-catenin蛋白在膀胱尿路上皮癌中的表达明显增强(P<0.05),并与病理分级、分期的程度成正比(P<0.05);EN2及β-catenin基因在膀胱尿路上皮癌中的表达也明显增强(P<0.05),并与病理分级、分期的程度成正比(P<0.05)。结论 EN2和β-catenin在膀胱尿路上皮癌中的表达明显增强;EN2可能通过激活Wnt/β-catenin信号通路,参与膀胱尿路上皮癌的发生、发展。
目的探討膀胱尿路上皮癌中EN2與β-catenin的錶達及其意義。方法選取60例手術切除的不同病理分級和分期的膀胱尿路上皮癌組織和10例正常膀胱粘膜組織。通過免疫組織化學、Western blot及RT-PCR方法分彆檢測EN2與β-catenin蛋白和基因的錶達情況。結果 EN2及β-catenin蛋白在膀胱尿路上皮癌中的錶達明顯增彊(P<0.05),併與病理分級、分期的程度成正比(P<0.05);EN2及β-catenin基因在膀胱尿路上皮癌中的錶達也明顯增彊(P<0.05),併與病理分級、分期的程度成正比(P<0.05)。結論 EN2和β-catenin在膀胱尿路上皮癌中的錶達明顯增彊;EN2可能通過激活Wnt/β-catenin信號通路,參與膀胱尿路上皮癌的髮生、髮展。
목적탐토방광뇨로상피암중EN2여β-catenin적표체급기의의。방법선취60례수술절제적불동병리분급화분기적방광뇨로상피암조직화10례정상방광점막조직。통과면역조직화학、Western blot급RT-PCR방법분별검측EN2여β-catenin단백화기인적표체정황。결과 EN2급β-catenin단백재방광뇨로상피암중적표체명현증강(P<0.05),병여병리분급、분기적정도성정비(P<0.05);EN2급β-catenin기인재방광뇨로상피암중적표체야명현증강(P<0.05),병여병리분급、분기적정도성정비(P<0.05)。결론 EN2화β-catenin재방광뇨로상피암중적표체명현증강;EN2가능통과격활Wnt/β-catenin신호통로,삼여방광뇨로상피암적발생、발전。
Objective To investigate the expressions of Engrailed-2 (EN2) and β-catenin in bladder urothelial carcinoma and explore their significance. Methods Sixty bladder urothelial carcinoma samples of different grades and stages and 10 normal bladder mucosal tissues were examined for expressions of EN2 and β-catenin proteins and mRNA using immunochemistry, Western blotting and RT-PCR. Results Compared to normal bladder mucosa, bladder urothelial carcinoma tissues showed significantly increased expressions of EN2 and β-catenin proteins (P<0.05), and the high-grade carcinoma tissues exhibited significantly stronger expressions than the low-grade ones (P<0.05);the expressions of the proteins increased also significantly with advanced pathological stages of bladder urothelial carcinoma (P<0.05). The expressions of EN2 and β-catenin mRNAs showed a consistent pattern of changes with their protein expressions. Conclusion The expressions of EN2 andβ-catenin are significantly increased in bladder urothelial carcinoma. EN2 may contribute to the development and progression of bladder urothelial carcinoma by activating Wnt/β-catenin signal pathway.