中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2013年
9期
868-870
,共3页
张冬坤%苏晓东%张旭%张兰军%胡祎%戎铁华
張鼕坤%囌曉東%張旭%張蘭軍%鬍祎%戎鐵華
장동곤%소효동%장욱%장란군%호의%융철화
食管肿瘤%青年人%临床病理特征%预后
食管腫瘤%青年人%臨床病理特徵%預後
식관종류%청년인%림상병리특정%예후
Esophageal neoplasms%Young%Clinicopathological features%Prognosis
目的 探讨青年人与中老年人食管癌的临床病理特征及预后的差异.方法 回顾性分析1990年1月至1998年12月间在中山大学肿瘤防治中心接受手术治疗的716例食管鳞状细胞癌患者的临床资料,对其中117例45岁以下(青年组)和599例大于45岁(中老年组)患者的临床病理特征及预后进行对比分析.结果 除肿瘤分期外,青年组与中老年组临床病理特征的差异均无统计学意义(均P＞0.05).青年组Ⅲ期患者所占比例为47.9％(56/117),明显高于中老年组的33.6％(201/599,P=0.010).但青年组与中老年组患者的预后差异并无统计学意义(5年生存率:36.0％比33.8％,10年生存率:29.2％比25.0％,P=0.418).多因素预后分析显示,患者年龄不是食管癌的独立预后因素(P=0.160,RR=1.187,95％CI:0.935～1.506).结论 尽管青年人食管癌的病理分期较晚,但其预后与中老年人并无明显差异.
目的 探討青年人與中老年人食管癌的臨床病理特徵及預後的差異.方法 迴顧性分析1990年1月至1998年12月間在中山大學腫瘤防治中心接受手術治療的716例食管鱗狀細胞癌患者的臨床資料,對其中117例45歲以下(青年組)和599例大于45歲(中老年組)患者的臨床病理特徵及預後進行對比分析.結果 除腫瘤分期外,青年組與中老年組臨床病理特徵的差異均無統計學意義(均P＞0.05).青年組Ⅲ期患者所佔比例為47.9％(56/117),明顯高于中老年組的33.6％(201/599,P=0.010).但青年組與中老年組患者的預後差異併無統計學意義(5年生存率:36.0％比33.8％,10年生存率:29.2％比25.0％,P=0.418).多因素預後分析顯示,患者年齡不是食管癌的獨立預後因素(P=0.160,RR=1.187,95％CI:0.935～1.506).結論 儘管青年人食管癌的病理分期較晚,但其預後與中老年人併無明顯差異.
목적 탐토청년인여중노년인식관암적림상병리특정급예후적차이.방법 회고성분석1990년1월지1998년12월간재중산대학종류방치중심접수수술치료적716례식관린상세포암환자적림상자료,대기중117례45세이하(청년조)화599례대우45세(중노년조)환자적림상병리특정급예후진행대비분석.결과 제종류분기외,청년조여중노년조림상병리특정적차이균무통계학의의(균P＞0.05).청년조Ⅲ기환자소점비례위47.9％(56/117),명현고우중노년조적33.6％(201/599,P=0.010).단청년조여중노년조환자적예후차이병무통계학의의(5년생존솔:36.0％비33.8％,10년생존솔:29.2％비25.0％,P=0.418).다인소예후분석현시,환자년령불시식관암적독립예후인소(P=0.160,RR=1.187,95％CI:0.935～1.506).결론 진관청년인식관암적병리분기교만,단기예후여중노년인병무명현차이.
Objective To compare the clinicopathological features and prognosis of esophageal cancer between young and elderly patients.Methods Clinical data of 716 patients with esophageal squamous cell carcinoma undergoing curative operation from January 1990 to December 1998 at the Cancer Center of Sun Yat-sen University were analyzed retrospectively.Clinicopathological features and prognosis of 117 patients aged ≤45 years (young group) at diagnosis were compared with 599 patients aged ＞45 years (elderly group).Results Except for tumor stage,there were no significant differences of clinicopathology between the young group and the elderly group (all P＞0.05).There were more pathologic stage Ⅲ cancer in the young group than the elderly group(47.9％ vs.33.6％,P=0.010).The 5-year survival rate (36.0％ vs 33.8％) and 10-year survival rate (29.2％ vs 25.0％) were not significantly different between the two groups (P=0.418).Multivariate analysis showed that the age was not the independent prognostic factors of esophageal squamous cell carcinoma (P=0.160,RR=1.187,95％CI:0.935-1.506).Conclusion Young esophageal cancer patients have more advanced tumors than elderly patients.However,the survival is comparable to the elderly.
