CAJ | 학술논문

鸭坦布苏病毒是近年来在我国发现的可引起种（蛋）鸭高热、采食量和产蛋量骤降的新病毒。本研究以麻鸭为动物模型，测定麻鸭感染鸭坦布苏病毒后，其免疫器官指数、重组H5亚型禽流感病毒灭活疫苗和鸡新城疫病毒弱毒活疫苗诱导产生的抗体水平。结果表明，鸭坦布苏病毒感染会侵害麻鸭的免疫器官，第1～3d脾脏明显肿大，第7～10 d试验组胸腺指数极显著低于对照组，第1～14 d法氏囊出现萎缩；与仅免疫疫苗的对照组鸭相比，感染鸭坦布苏病毒后再注射疫苗的试验组鸭产生抗体的时间延迟、抗体的峰值降低，抗体下降加快，且在整个试验期内产生的抗体水平均低于对照组鸭的抗体水平，表明鸭坦布苏病毒感染可抑制鸭对灭活疫苗和弱毒疫苗的体液免疫应答能力。
압탄포소병독시근년래재아국발현적가인기충（단）압고열、채식량화산단량취강적신병독。본연구이마압위동물모형，측정마압감염압탄포소병독후，기면역기관지수、중조H5아형금류감병독멸활역묘화계신성역병독약독활역묘유도산생적항체수평。결과표명，압탄포소병독감염회침해마압적면역기관，제1～3d비장명현종대，제7～10 d시험조흉선지수겁현저저우대조조，제1～14 d법씨낭출현위축；여부면역역묘적대조조압상비，감염압탄포소병독후재주사역묘적시험조압산생항체적시간연지、항체적봉치강저，항체하강가쾌，차재정개시험기내산생적항체수평균저우대조조압적항체수평，표명압탄포소병독감염가억제압대멸활역묘화약독역묘적체액면역응답능력。
Duck Tembusu virus is a newly discovered virus in recent years ,which caused duck high fever ,egg-laying and feed intake decreased .In this study ,we used Sheldrake as animal model ,and infected with duck Tembusu virus .Then we determinated the immune organ indices and the antibody levels in ducks induced by recombinant H 5 avian influenza inactivated vaccine and Newcastle disease virus attenuated live vaccine , respectively .The results showed that the duck immune organs were violated after infected with duck Tembusu virus ,resulting in spleen enlargement (1 dpi to 3 dpi) ,bursa atrophy (1 dpi to 14 dpi) ,and the test group thymus index was significantly lower than the control group from 7 dpi to 10 dpi .Compared with immunized-group ,the antibodies level of the infected-immunized-group were delayed and low ,and reduction in peaks and declined accelerate throughout the test period .The above results indicated that duck Tembusu virus can affect the humor immune response to inactivated vaccine and attenuated vaccine in duck .