中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
10期
1508-1510
,共3页
美托咪啶%七氟烷%手术后并发症%麻醉
美託咪啶%七氟烷%手術後併髮癥%痳醉
미탁미정%칠불완%수술후병발증%마취
Dexmedetomidine%Sevoflurane%Postoperative complications%Anesthesia
目的 探讨右旋美托咪啶用于减轻小儿七氟烷麻醉术后急性躁动的有效剂量.方法 105例ASA Ⅰ～Ⅱ级行手术的患儿吸入3％七氟烷进行麻醉诱导,然后数字表法随机分为三组,每组35例,对照组注射0.9％氯化钠注射液,观察1组注射右旋美托咪啶0.15μg/kg,观察2组注射右旋美托咪啶0.30 μg/kg,然后放置口咽通气道辅助通气,行骶管阻滞.麻醉维持使用1.2％七氟烷,维持其自主通气.记录患儿血流动力学和呼吸的改变.在麻醉结束时记录睁眼时间(TEO).结果 三组患儿手术过程基本相似.对照组TEO为(8.45±4.02) min,短于观察l组的(9.23±5.03) min、观察2组的(10.81±4.06)min(t=1.23、1.64,均P＞0.05).对照组躁动发生率为42.8％,观察1组为20.0％,观察2组为8.6％,观察1组显著低于对照组(x2=3.72,P＜0.05),观察2组显著低于对照组和观察l组(x2=5.14、4.27,均P＜0.05).结论 右旋美托咪啶可有效预防小儿七氟烷麻醉术后急性躁动,0.30 lg/kg剂量既有效又安全.
目的 探討右鏇美託咪啶用于減輕小兒七氟烷痳醉術後急性躁動的有效劑量.方法 105例ASA Ⅰ～Ⅱ級行手術的患兒吸入3％七氟烷進行痳醉誘導,然後數字錶法隨機分為三組,每組35例,對照組註射0.9％氯化鈉註射液,觀察1組註射右鏇美託咪啶0.15μg/kg,觀察2組註射右鏇美託咪啶0.30 μg/kg,然後放置口嚥通氣道輔助通氣,行骶管阻滯.痳醉維持使用1.2％七氟烷,維持其自主通氣.記錄患兒血流動力學和呼吸的改變.在痳醉結束時記錄睜眼時間(TEO).結果 三組患兒手術過程基本相似.對照組TEO為(8.45±4.02) min,短于觀察l組的(9.23±5.03) min、觀察2組的(10.81±4.06)min(t=1.23、1.64,均P＞0.05).對照組躁動髮生率為42.8％,觀察1組為20.0％,觀察2組為8.6％,觀察1組顯著低于對照組(x2=3.72,P＜0.05),觀察2組顯著低于對照組和觀察l組(x2=5.14、4.27,均P＜0.05).結論 右鏇美託咪啶可有效預防小兒七氟烷痳醉術後急性躁動,0.30 lg/kg劑量既有效又安全.
목적 탐토우선미탁미정용우감경소인칠불완마취술후급성조동적유효제량.방법 105례ASA Ⅰ～Ⅱ급행수술적환인흡입3％칠불완진행마취유도,연후수자표법수궤분위삼조,매조35례,대조조주사0.9％록화납주사액,관찰1조주사우선미탁미정0.15μg/kg,관찰2조주사우선미탁미정0.30 μg/kg,연후방치구인통기도보조통기,행저관조체.마취유지사용1.2％칠불완,유지기자주통기.기록환인혈류동역학화호흡적개변.재마취결속시기록정안시간(TEO).결과 삼조환인수술과정기본상사.대조조TEO위(8.45±4.02) min,단우관찰l조적(9.23±5.03) min、관찰2조적(10.81±4.06)min(t=1.23、1.64,균P＞0.05).대조조조동발생솔위42.8％,관찰1조위20.0％,관찰2조위8.6％,관찰1조현저저우대조조(x2=3.72,P＜0.05),관찰2조현저저우대조조화관찰l조(x2=5.14、4.27,균P＜0.05).결론 우선미탁미정가유효예방소인칠불완마취술후급성조동,0.30 lg/kg제량기유효우안전.
Objective To investigate the effect of different dose dexmedetomidine on reducing agitation after sevoflurane anesthesia in patients underwent repair of indirect inguinal hernia.Methods 105 cases of ASA Ⅰ ～ Ⅱ received operation with inhalation of 3％ sevoflurane to induce anesthesia,and then randomly divided into three groups,35 cases in each group.The control group injected with 0.9％ sodium chloride,observation 1 group injected dexmedetomidine 0.15μg/kg,observation 2 group injected dexmedetomidine 0.30μ g/kg.Then placed oropharynx airway ventilation,caudal block.Anesthesia was maintained with 1.2％ sevoflurane,maintain its independent ventilation.Hemodynamic and respiratory changes of the children were recorded.Time to eye opening(TEO) at the end of anesthesia was also recorded.Results Three groups of children had similar operation process.TEO of the control group was (8.45 ± 4.02) min,observation 1 group was (9.23 ± 5.03) min,observation 2 group was (10.81 ± 4.06) min (t =1.23,1.64,all P ＞ 0.05).The incidence rate of agitation of the control group was 42.8％,that in the observation 1 group and observation 2 group was 20％,8.6％.Observation 1 group was significantly lower than that of control group (x2 =3.72,P ＜ 0.05),observation 2 group was significantly lower than that of control group and observation 1 group (x2 =5.14,4.27,all P ＜ 0.05).Conclusion The dose of dexmedetomidine 0.3 μg/kg administered after induction of anesthesia could reduce the postsevoflurane agitation in children and have no adverse effects.
