国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2014年
4期
171-174
,共4页
高血压%巨细胞病毒感染%中和抗体
高血壓%巨細胞病毒感染%中和抗體
고혈압%거세포병독감염%중화항체
Hypertension%Cytomegalovirus infection%Neutralizing antibodies
目的 对高血压患者人巨细胞病毒(HCMV)感染率及其血浆中和抗体水平展开研究分析,研究高血压与人巨细胞病毒感染的相关性.方法 随机选取2011年12月-2013年12月期间接收治疗的50例高血压患者血标本作为观察组,同时选取50例健康体检人员的血标本作为对照组.对两组标本人巨细胞病毒特异性中和抗体、人巨细胞病毒特异性IgG和IgM、人巨细胞病毒特异性UL93 DNA进行检测.结果 观察组HCMV UL93 DNA的阳性率为72.0％,HCMV IgG阳性率为70.0％,HCMV IgM阳性率为4.0％;对照组HCMV UL93 DNA阳性率为54.0％,HCMV IgG阳性率为52.0％,HCMV IgM阳性率为2.0％;观察组HCMV UL93 DNA阳性率、HCMV IgG阳性率显著高于对照组,数据差异具有统计学意义(P＜0.05);两组HCMV IgM阳性率数据对比差异无统计学意义(P＞0.05).结论 高血压患者人巨细胞病毒感染率显著高于健康对照组,但特异性中和抗体水平较健康对照组显著下降,即高血压患者的人巨细胞病毒感染体液免疫状态不足,高血压与人巨细胞病毒感染显著相关.
目的 對高血壓患者人巨細胞病毒(HCMV)感染率及其血漿中和抗體水平展開研究分析,研究高血壓與人巨細胞病毒感染的相關性.方法 隨機選取2011年12月-2013年12月期間接收治療的50例高血壓患者血標本作為觀察組,同時選取50例健康體檢人員的血標本作為對照組.對兩組標本人巨細胞病毒特異性中和抗體、人巨細胞病毒特異性IgG和IgM、人巨細胞病毒特異性UL93 DNA進行檢測.結果 觀察組HCMV UL93 DNA的暘性率為72.0％,HCMV IgG暘性率為70.0％,HCMV IgM暘性率為4.0％;對照組HCMV UL93 DNA暘性率為54.0％,HCMV IgG暘性率為52.0％,HCMV IgM暘性率為2.0％;觀察組HCMV UL93 DNA暘性率、HCMV IgG暘性率顯著高于對照組,數據差異具有統計學意義(P＜0.05);兩組HCMV IgM暘性率數據對比差異無統計學意義(P＞0.05).結論 高血壓患者人巨細胞病毒感染率顯著高于健康對照組,但特異性中和抗體水平較健康對照組顯著下降,即高血壓患者的人巨細胞病毒感染體液免疫狀態不足,高血壓與人巨細胞病毒感染顯著相關.
목적 대고혈압환자인거세포병독(HCMV)감염솔급기혈장중화항체수평전개연구분석,연구고혈압여인거세포병독감염적상관성.방법 수궤선취2011년12월-2013년12월기간접수치료적50례고혈압환자혈표본작위관찰조,동시선취50례건강체검인원적혈표본작위대조조.대량조표본인거세포병독특이성중화항체、인거세포병독특이성IgG화IgM、인거세포병독특이성UL93 DNA진행검측.결과 관찰조HCMV UL93 DNA적양성솔위72.0％,HCMV IgG양성솔위70.0％,HCMV IgM양성솔위4.0％;대조조HCMV UL93 DNA양성솔위54.0％,HCMV IgG양성솔위52.0％,HCMV IgM양성솔위2.0％;관찰조HCMV UL93 DNA양성솔、HCMV IgG양성솔현저고우대조조,수거차이구유통계학의의(P＜0.05);량조HCMV IgM양성솔수거대비차이무통계학의의(P＞0.05).결론 고혈압환자인거세포병독감염솔현저고우건강대조조,단특이성중화항체수평교건강대조조현저하강,즉고혈압환자적인거세포병독감염체액면역상태불족,고혈압여인거세포병독감염현저상관.
Objective To analysis of human cytomegalovirus infection and antibody levels in plasma for hypertensive patients and explore the relationship of hypertension and human cytomegalovirus infection.Methods 50 hypertensive patients were selected as experiment group during December 2011 to December 2013 and 50 healthy people as control group.Human cytomegalovirus-specific neutralizing antibodies,human cytomegalovirus-specific IgG and IgM,human cytomegalovirus UL93DNA were tested from blood sampls for two groups.Results The positive rate of HCMV UL93 DNA was 72.0％,The positive rate of HCMV IgG was 70.0％,The positive rate of HCMV IgM was 4.0％.For control group,the positive rate of HCMV UL93 DNA was 54.0％,The positive rate of HCMV IgG was 52.0％,The positive rate of HCMV IgM was 2.0％.There were statistical difference between the positive rate of HCMV UL93 DNA for experiment group and control group (P ＜ 0.05),between the positive rate of HCMV IgG for experiment group and control group (P ＜ 0.05).There was no statistical difference between the positive rate of groups HCMV IgM between two group (P ＞ 0.05).Conclusions Hypertension patients had more chances to infect with human cytomegalovirus because of lower immunity ability,and there was association with hypertension and CMV infection.
