实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
8期
1032-1034
,共3页
宫颈癌%根治性子宫切除术%同步放化疗%预后
宮頸癌%根治性子宮切除術%同步放化療%預後
궁경암%근치성자궁절제술%동보방화료%예후
Cervical carcinoma%Radical hysterectomy%Concurrent chemoradiotherapy%Prognosis
目的：探讨根治性子宫切除术联合术前同步放化疗治疗局部晚期宫颈癌的临床疗效及预后多因素分析。方法选择四川大学华西第二医院诊治的160例局部晚期宫颈癌患者临床资料进行回顾性分析。所有患者均行根治性子宫切除术，其中78例患者（ A组）术前行放疗治疗，82例患者（ B组）行术前同步放化疗。比较2组患者5年生存率、5年无瘤生存率的差别，并对患者预后进行Cox多因素分析。结果 B组5年生存率与5年无瘤生存率显著优于A组（ P＜0．05）。单因素分析结果显示：肿瘤直径、年龄、淋巴结转移、同步放化疗与患者生存率相关；多因素分析结果显示：肿瘤直径、淋巴结转移及同步放化疗是影响患者预后的独立因素。结论根治性子宫切除术联合术前同步放化疗可显著延长局部晚期宫颈癌生存期，肿瘤直径、淋巴结转移及同步放化疗是影响患者预后的独立因素。
目的：探討根治性子宮切除術聯閤術前同步放化療治療跼部晚期宮頸癌的臨床療效及預後多因素分析。方法選擇四川大學華西第二醫院診治的160例跼部晚期宮頸癌患者臨床資料進行迴顧性分析。所有患者均行根治性子宮切除術，其中78例患者（ A組）術前行放療治療，82例患者（ B組）行術前同步放化療。比較2組患者5年生存率、5年無瘤生存率的差彆，併對患者預後進行Cox多因素分析。結果 B組5年生存率與5年無瘤生存率顯著優于A組（ P＜0．05）。單因素分析結果顯示：腫瘤直徑、年齡、淋巴結轉移、同步放化療與患者生存率相關；多因素分析結果顯示：腫瘤直徑、淋巴結轉移及同步放化療是影響患者預後的獨立因素。結論根治性子宮切除術聯閤術前同步放化療可顯著延長跼部晚期宮頸癌生存期，腫瘤直徑、淋巴結轉移及同步放化療是影響患者預後的獨立因素。
목적：탐토근치성자궁절제술연합술전동보방화료치료국부만기궁경암적림상료효급예후다인소분석。방법선택사천대학화서제이의원진치적160례국부만기궁경암환자림상자료진행회고성분석。소유환자균행근치성자궁절제술，기중78례환자（ A조）술전행방료치료，82례환자（ B조）행술전동보방화료。비교2조환자5년생존솔、5년무류생존솔적차별，병대환자예후진행Cox다인소분석。결과 B조5년생존솔여5년무류생존솔현저우우A조（ P＜0．05）。단인소분석결과현시：종류직경、년령、림파결전이、동보방화료여환자생존솔상관；다인소분석결과현시：종류직경、림파결전이급동보방화료시영향환자예후적독립인소。결론근치성자궁절제술연합술전동보방화료가현저연장국부만기궁경암생존기，종류직경、림파결전이급동보방화료시영향환자예후적독립인소。
Objective To explore the clinical efficacy of radical hysterectomy and preoperative concurrent chemoradio -therapy for locally advanced cervical carcinoma and multiple factors analysis of prognosis .Methods The data of 160 cases of lo-cally advanced cervical carcinoma were retrospectively analyzed .All the subjects underwent radical hysterectomy .78 cases in group A were given preoperative radiotherapy and 82 cases of group B received concurrent chemoradiotherapy .5-year survival rates and 5-year disease free survival rates were compared between the 2 groups,and the prognosis was analyzed by multivariate cox analysis.Results 5-year survival rates and 5-year disease free survival in group B were superior to group A (P<0.05);Un-ivariate analysis results showed that tumor diameter , age, lymphatic metastasis and preoperative concurrent chemoradiotherapy were related with survival rate .Multivariate cox analysis results showed that tumor diameter ,lymphatic metastasis and preoperative concurrent chemoradiotherapy were the independence factors for prognosis .Conclusion Radical hysterectomy and preoperative concurrent chemoradiotherapy for locally advanced cervical carcinoma greatly prolong the survival period .Tumor diameter ,lym-phatic metastasis and preoperative concurrent chemoradiotherapy are the independent factors for prognosis .
