实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
8期
1027-1029
,共3页
基因重组人粒细胞集落刺激因子%急性淋巴细胞白血病%化疗%CODP方案
基因重組人粒細胞集落刺激因子%急性淋巴細胞白血病%化療%CODP方案
기인중조인립세포집락자격인자%급성림파세포백혈병%화료%CODP방안
Recombinant human granulocyte colony stimulating factor ( rhG-CSF)%Acute lymphoblastic leukemia%Chem-otherapy%CODP regimen
目的：探讨基因重组人粒细胞集落刺激因子（ rhG-CSF）在急性淋巴细胞白血病患儿CODP方案化疗中的辅助作用。方法选取急性淋巴细胞白血病化疗患儿80例，根据不同治疗方法将患者分为观察组和对照组，各40例。对照组给予CODP（柔红霉素、长春新碱、环磷酰胺、泼尼松）方案化疗，观察组在对照组基础上给予rhG-CSF辅助化疗，比较2组患儿化疗效果。结果观察组完全缓解率为100．0％，对照组完全缓解率92．5％、部分缓解率7．5％，2组患儿化疗总有效率比较差异无统计学意义（P＞0．05）。观察组骨髓抑制（白细胞计数、中性粒细胞和血小板计数下降）和口腔感染发生率明显低于对照组，中性粒细胞恢复时间、白细胞恢复时间和发热持续时间亦明显少于对照组，2组比较差异具有统计学意义（P＜0．05）。结论 rhG-CSF辅助急性淋巴细胞白血病CODP方案化疗对改善化疗引起的骨髓抑制、降低感染具有重要的临床意义。
目的：探討基因重組人粒細胞集落刺激因子（ rhG-CSF）在急性淋巴細胞白血病患兒CODP方案化療中的輔助作用。方法選取急性淋巴細胞白血病化療患兒80例，根據不同治療方法將患者分為觀察組和對照組，各40例。對照組給予CODP（柔紅黴素、長春新堿、環燐酰胺、潑尼鬆）方案化療，觀察組在對照組基礎上給予rhG-CSF輔助化療，比較2組患兒化療效果。結果觀察組完全緩解率為100．0％，對照組完全緩解率92．5％、部分緩解率7．5％，2組患兒化療總有效率比較差異無統計學意義（P＞0．05）。觀察組骨髓抑製（白細胞計數、中性粒細胞和血小闆計數下降）和口腔感染髮生率明顯低于對照組，中性粒細胞恢複時間、白細胞恢複時間和髮熱持續時間亦明顯少于對照組，2組比較差異具有統計學意義（P＜0．05）。結論 rhG-CSF輔助急性淋巴細胞白血病CODP方案化療對改善化療引起的骨髓抑製、降低感染具有重要的臨床意義。
목적：탐토기인중조인립세포집락자격인자（ rhG-CSF）재급성림파세포백혈병환인CODP방안화료중적보조작용。방법선취급성림파세포백혈병화료환인80례，근거불동치료방법장환자분위관찰조화대조조，각40례。대조조급여CODP（유홍매소、장춘신감、배린선알、발니송）방안화료，관찰조재대조조기출상급여rhG-CSF보조화료，비교2조환인화료효과。결과관찰조완전완해솔위100．0％，대조조완전완해솔92．5％、부분완해솔7．5％，2조환인화료총유효솔비교차이무통계학의의（P＞0．05）。관찰조골수억제（백세포계수、중성립세포화혈소판계수하강）화구강감염발생솔명현저우대조조，중성립세포회복시간、백세포회복시간화발열지속시간역명현소우대조조，2조비교차이구유통계학의의（P＜0．05）。결론 rhG-CSF보조급성림파세포백혈병CODP방안화료대개선화료인기적골수억제、강저감염구유중요적림상의의。
Objective To investigate the auxiliary effect of recombinant human granulocyte colony stimulating factor ( rhG-CSF) in CODP chemotherapy for children with acute lymphoblastic leukemia .Methods 80 children with acute lympho-blastic leukemia treated with chemotherapy were divided into the observation group and the control group according to different treatment methods,each with 40 cases.The control group was given CODP (daunorubicin,vincristine,cyclophosphamide,predni-son) chemotherapy ,and the observation group additionally received rhG-CSF adjuvant chemotherapy ,the effects of the 2 groups werecompared.Results Complete remission rate in the observation group was 100.0%,complete remission rate in the control group was 92.5%,and partial remission rate was 7.5%,there had no significant difference (P>0.05).Bone marrow depression (decreased white blood cell count ,neutrophil,platelet count drop) and oral infection rate in the observation group were signifi-cantly lower than those of the control group ,the neutrophil recovery time ,WBC recovery time and duration of fever in the observa-tion group were obviously less than those of the control group ,there had significant difference (P<0.05).Conclusion rhG-CSF CODP adjuvant chemotherapy for acute lymphoblastic leukemia has important clinical significance in improving bone marrow sup -pression and reducing infection .
