CAJ | 학술논문

目的：探讨白血病患儿并发活动性结核病的临床特征、诊治情况及相关危险因素。方法选取并分析华西第二医院感染科接诊的30例并发活动性结核病的白血病患儿（0～10岁）的临床资料，了解其临床特征、治疗效果及其影响因素。结果年龄较低（≤5岁）的女性患儿中性粒细胞≤0．5×109/L的比例更大（P＜0．05）；不同诊断方法确诊结核病构成比具有统计学差异（χ2＝18．093，P＝0．001）；年龄、性别、二病诊断时间间隔、一线抗结核方案效果、预后、中性粒细胞绝对数是白血病并发结核病患儿抗结核治疗效果的影响因素。结论若条件允许，可选择多种诊断方法以增强诊断的可靠性；根据白血病合并结核病的患儿的具体情况及抗结核治疗的影响因素选择个性化的综合治疗方案。
목적：탐토백혈병환인병발활동성결핵병적림상특정、진치정황급상관위험인소。방법선취병분석화서제이의원감염과접진적30례병발활동성결핵병적백혈병환인（0～10세）적림상자료，료해기림상특정、치료효과급기영향인소。결과년령교저（≤5세）적녀성환인중성립세포≤0．5×109/L적비례경대（P＜0．05）；불동진단방법학진결핵병구성비구유통계학차이（χ2＝18．093，P＝0．001）；년령、성별、이병진단시간간격、일선항결핵방안효과、예후、중성립세포절대수시백혈병병발결핵병환인항결핵치료효과적영향인소。결론약조건윤허，가선택다충진단방법이증강진단적가고성；근거백혈병합병결핵병적환인적구체정황급항결핵치료적영향인소선택개성화적종합치료방안。
Objective To analyze the clinical characteristics ,diagnosis,treatment and risk factors of children with leuke-mia complicated with active TB .Methods Clinical data of 30 children with leukemia and active TB disease was analyzed to un-derstand its clinical features ,treatment and influencing factors .Results Lower age (≤5 years ) female patients whose neutro-phils ≤0.5 ×109/L had a greater proportion (P<0.05);proportions of TB diagnosis from different diagnostic approaches had a significant difference (χ2 =18.093,P=0.001);age,gender,time interval between leukemia diagnosis and active TB ,the effect of first-line anti-TB program,prognosis,absolute neutrophils were the risk factors of anti-TB treatment.Conclusion If conditions permit,a variety of diagnostic methods should be chosen to enhance the reliability of the diagnosis ;the individualized comprehen-sive treatment program based on the factors of of anti-TB treatment should be selected .