CAJ | 학술논문

目的：探讨血红蛋白改变对晚期胃癌患者化疗疗效及预后的预测价值。方法收集我院76例晚期胃癌患者的临床资料，应用SPSS18．0软件对化疗前后血红蛋白的改变与晚期胃癌患者化疗疗效和预后的关系进行相关分析。结果化疗前后，男性患者的血红蛋白分别为（116．72±22．01） g/L和（111．28±18．97） g/L，肝转移的患者血红蛋白分别为（116．28±18．85） g/L 和（110．06±18．73） g/L，内脏转移的患者血红蛋白分别为（115．27±18．66） g/L 和（109．53±18．06）g/L，差异均具有统计学意义（P＜0．05）。但化疗前后血红蛋白的变化和其他参数如年龄、ECOG评分、病理分型及腹膜转移等因素无相关性。生存分析显示在化疗前出现贫血的胃癌患者的预后较差，但是差异无统计学意义（P＞0．05）。结论晚期胃癌患者血红蛋白的改变与化疗疗效有密切关系，化疗后血红蛋白降低提示疗效较差，而化疗前无贫血的晚期胃癌患者显示出比较好的预后。
목적：탐토혈홍단백개변대만기위암환자화료료효급예후적예측개치。방법수집아원76례만기위암환자적림상자료，응용SPSS18．0연건대화료전후혈홍단백적개변여만기위암환자화료료효화예후적관계진행상관분석。결과화료전후，남성환자적혈홍단백분별위（116．72±22．01） g/L화（111．28±18．97） g/L，간전이적환자혈홍단백분별위（116．28±18．85） g/L 화（110．06±18．73） g/L，내장전이적환자혈홍단백분별위（115．27±18．66） g/L 화（109．53±18．06）g/L，차이균구유통계학의의（P＜0．05）。단화료전후혈홍단백적변화화기타삼수여년령、ECOG평분、병리분형급복막전이등인소무상관성。생존분석현시재화료전출현빈혈적위암환자적예후교차，단시차이무통계학의의（P＞0．05）。결론만기위암환자혈홍단백적개변여화료료효유밀절관계，화료후혈홍단백강저제시료효교차，이화료전무빈혈적만기위암환자현시출비교호적예후。
Objective To explore the predictive value of hemoglobin change on chemotherapy and prognosis of patients with advanced gastric cancer .Methods Clinical data of 76 cases of advanced gastric cancer patients were analyzed .The correla-tion between hemoglobin change and the efficacy and prognosis of patients with advanced gastric cancer were analyzed by software SPSS18.0.Results The changes of hemoglobin were analyzed before and after chemotherapy ,the male patients were(116.72 ± 22.01)g/L and(111.28 ±18.97)g/L,patients with liver metastasis were(116.28 ±18.85)g/L and(110.06 ±18.73)g/L, and patients with visceral metastases were (115.27 ±18.66)g/L and(109.53 ±18.06)g/L,respectively,the differences had statistical significance(P<0.05).The changes of hemoglobin were not related with other parameters such as age ,ECOG score, pathological typing and peritoneal metastasis .Survival analysis showed that gastric cancer patients with anemia before chemothera -py had poor prognosis,but the difference was not statistically significant (P>0.05).Conclusion There is a close relationship between the hemoglobin changes and the efficacy of chemotherapy in patients with advanced gastric cancer .Decreased hemoglobin after chemotherapy suggests poor efficacy .Patients without anemia before chemotherapy shows a relatively good prognosis .