CAJ | 학술논문

目的：分析阿米福汀在鼻咽癌放疗中对正常组织的保护作用。方法选取2010年1月至2012年12月我科收治入院的鼻咽癌患者42例，分为阿米福汀组和对照组。阿米福汀组于放疗前30 min静脉滴注阿米福汀，对照组则进行常规放疗治疗，观察和比较两组患者放疗后产生的皮肤损伤、口腔黏膜损伤、口干等急性放射性损伤以及恶心呕吐等毒副反应。结果经阿米福汀联合治疗的患者放射性皮肤损伤、口腔黏膜损伤、口干等反应较对照组患者轻，具有统计学意义。结论阿米福汀在鼻咽癌放疗中能够保护正常组织细胞，有效降低了患者放射性损伤。
목적：분석아미복정재비인암방료중대정상조직적보호작용。방법선취2010년1월지2012년12월아과수치입원적비인암환자42례，분위아미복정조화대조조。아미복정조우방료전30 min정맥적주아미복정，대조조칙진행상규방료치료，관찰화비교량조환자방료후산생적피부손상、구강점막손상、구간등급성방사성손상이급악심구토등독부반응。결과경아미복정연합치료적환자방사성피부손상、구강점막손상、구간등반응교대조조환자경，구유통계학의의。결론아미복정재비인암방료중능구보호정상조직세포，유효강저료환자방사성손상。
Objective To evaluate Amifostine effect on protecting normal tissue from radiation therapy due to NPC . Methods Forty two patients of NPC were divided into two groups .Radiation therapy(70 Gy)was given to all the patients.Ami-fostin was injected into the patients before 30 min in the treatment group .The control group without Amifostine .The radiation-in-duced skin damage、catarrh of oral cavity、xerostomia and side-effect were evaluated respectively .Results The radiation-induced skin damage、catarrh of oral cavity and xerostomia in the treatment group were remarkly slighter than in the control group .Conclu-sion Amifostine is able to protect normal tissue from radiation therapy due to NPC .