CAJ | 학술논문

目的：探讨丙泊酚和七氟醚对老年肺癌患者术后认知功能的影响。方法选取2012年2月-2014年2月拟行手术治疗的Ⅰ～Ⅱ级肺癌患者64例，随机分为丙泊酚组和七氟醚组，每组各32例。丙泊酚组和七氟醚组分别使用丙泊酚和七氟醚进行全身麻醉。记录各组患者自主呼吸恢复时间、呼之睁眼时间和定向力恢复时间，并使用简易精神状态量表（ mini-mental state examination ，MMSE）和视觉模拟评分法（ visual analogue score ，VAS）对患者认知功能和疼痛进行评估。结果丙泊酚组呼吸恢复时间、呼之睁眼时间、定向力恢复时间与七氟醚组比较，P＜0．05，差异具有统计学意义。丙泊酚组术后6 h、12 h、24 h 的MMSE评分与术前比较，P＜0．05，差异具有统计学意义；七氟醚组术后6 h、12 h、24 h、3 d的MMSE评分与术前比较，P＜0．05，差异具有统计学意义。丙泊酚组术后6 h、术后12 h MMSE评分与七氟醚组比较，P＜0．05，差异具有统计学意义。结论丙泊酚对老年肺癌患者术后认知功能的影响小，患者术后苏醒快。
목적：탐토병박분화칠불미대노년폐암환자술후인지공능적영향。방법선취2012년2월-2014년2월의행수술치료적Ⅰ～Ⅱ급폐암환자64례，수궤분위병박분조화칠불미조，매조각32례。병박분조화칠불미조분별사용병박분화칠불미진행전신마취。기록각조환자자주호흡회복시간、호지정안시간화정향력회복시간，병사용간역정신상태량표（ mini-mental state examination ，MMSE）화시각모의평분법（ visual analogue score ，VAS）대환자인지공능화동통진행평고。결과병박분조호흡회복시간、호지정안시간、정향력회복시간여칠불미조비교，P＜0．05，차이구유통계학의의。병박분조술후6 h、12 h、24 h 적MMSE평분여술전비교，P＜0．05，차이구유통계학의의；칠불미조술후6 h、12 h、24 h、3 d적MMSE평분여술전비교，P＜0．05，차이구유통계학의의。병박분조술후6 h、술후12 h MMSE평분여칠불미조비교，P＜0．05，차이구유통계학의의。결론병박분대노년폐암환자술후인지공능적영향소，환자술후소성쾌。
Objective To investigate the effects of propofol and sevoflurane on cognitive function of elderly patients with lung cancer after operation .Methods 64 cases of lung cancer patients underwent surgical operation were randomly divided into the propofol group and the sevoflurane group ,32 patients in each group .The propofol group and sevoflurane group used propofol and sevoflurane for general anesthesia ,respectively .Spontaneous breathing recovery time ,called the open time and recovery time were recorded ,and cognitive function and pain were evaluated by mini-mental state examination ( MMSE ) and visual analogue score ( VAS) .Results Breathing recovery time ,called the open time and recovery time of orientation between the propofol group and sevoflurane group had statistical difference ,P<0.05;postoperative and preoperative 6 h,12 h and 24 h MMSE score in the propofol group had statistical difference ,P<0.05;postoperative and preoperative 6 h,12 h,24 h and 3 d MMSE score in the sevoflurane group had statistical difference ,P<0.05;postoperative 6 h and 12 h MMSE score between the propofol group and sevoflurane group had statistical difference ,P<0.05.Conclusion Effect of propofol on the cognitive function of postoperative elderly patients with lung cancer is slight ,and it has faster postoperative recovery .