CAJ | 학술논문

目的：探讨EP方案耐药广泛期小细胞肺癌安全有效的二线化疗方案。方法根据治疗方案将87例EP方案耐药广泛期小细胞肺癌患者分为观察组（45例）与对照组（42例），观察组接受IN方案治疗，对照组接受CAV方案治疗。化疗2个周期后进行疗效评价，同时采用抗肿瘤药物不良反应分级标准（ WHO标准）进行安全性评价。结果①观察组治疗效果显著优于对照组，差异有统计学意义（P＜0．05）。②2组患者骨髓抑制、呕吐等不良反应分级差异无统计学意义（P＞0．05）；观察组腹泻程度显著重于对照组，差异有统计学意义（P＜0．05）。所有发生不良反应的患者经对症支持治疗后均得到缓解。结论 IN方案治疗EP方案耐药广泛期小细胞肺癌具有安全、有效等特点，值得临床应用及推广。
목적：탐토EP방안내약엄범기소세포폐암안전유효적이선화료방안。방법근거치료방안장87례EP방안내약엄범기소세포폐암환자분위관찰조（45례）여대조조（42례），관찰조접수IN방안치료，대조조접수CAV방안치료。화료2개주기후진행료효평개，동시채용항종류약물불량반응분급표준（ WHO표준）진행안전성평개。결과①관찰조치료효과현저우우대조조，차이유통계학의의（P＜0．05）。②2조환자골수억제、구토등불량반응분급차이무통계학의의（P＞0．05）；관찰조복사정도현저중우대조조，차이유통계학의의（P＜0．05）。소유발생불량반응적환자경대증지지치료후균득도완해。결론 IN방안치료EP방안내약엄범기소세포폐암구유안전、유효등특점，치득림상응용급추엄。
Objective To investigate the safe and effective second-line chemotherapy regimen for EP-resistant extensive-stage small cell lung cancer .Methods According to the chemotherapy regimen ,87 cases of EP-resistant extensive-stage small cell lung cancer were divided into the observation group (45 cases) and the control group(42 cases),and the observation group received IN,while the control group received CAV.The therapeutic efficacy was evaluated after 2 cycles of chemotherapy,and safety was evaluated by the grading standard of adverse reaction for anti -tumor drugs ( WHO standard ) .Results ① The thera-peutic efficacy of the observation group was significantly better than that of the control group (P<0.05).②There were no signifi-cant difference in the severity of bone marrow depression and vomit between the 2 groups(P>0.05),while the severity of diar-rhea of the observation group was much more serious than that of the control group (P<0.05).All patients with adverse reactions were relieved after symptomatic and supportive treatment .Conclusion IN for EP-resistant extensive-stage small cell lung cancer is safe and efficient ,and it is worthy of clinical application .