CAJ | 학술논문

目的：探讨DKK-1、GSK-3β、PGSK-3β在宫颈鳞癌组织中的表达及与其发生发展、临床病理特征的关系。方法收集病理组织标本：包括慢性宫颈炎25例，宫颈上皮内瘤变29例，宫颈鳞癌41例，采用免疫组织化学染色法分别检测其中DKK-1、GSK-3β、PGSK-3β的表达情况。结果慢性宫颈炎、宫颈上皮内瘤变组织中DKK-1阳性表达率均明显高于宫颈鳞癌（P＜0．05）。慢性宫颈炎组织中GSK-3β阳性表达率明显高于宫颈癌组织（P＜0．05），而PGSK-3β阳性表达率低于宫颈癌组织（ P＜0．05）；DKK-1、PGSK-3β阳性表达与宫颈鳞癌组织分化、FIGO临床分期及有无淋巴结转移显著相关（P＜0．05）；PGSK-3β蛋白表达量CIN Ⅰ、CINⅡ～Ⅲ及宫颈鳞癌组织明显高于慢性宫颈炎组织（P＜0．05）；CINⅠ中PGSK-3β蛋白表达量明显高于宫颈癌组织（P＜0．05）。结论 DKK-1、GSK-3β、PGSK-3β表达与宫颈鳞癌的发生、发展密切相关。
목적：탐토DKK-1、GSK-3β、PGSK-3β재궁경린암조직중적표체급여기발생발전、림상병리특정적관계。방법수집병리조직표본：포괄만성궁경염25례，궁경상피내류변29례，궁경린암41례，채용면역조직화학염색법분별검측기중DKK-1、GSK-3β、PGSK-3β적표체정황。결과만성궁경염、궁경상피내류변조직중DKK-1양성표체솔균명현고우궁경린암（P＜0．05）。만성궁경염조직중GSK-3β양성표체솔명현고우궁경암조직（P＜0．05），이PGSK-3β양성표체솔저우궁경암조직（ P＜0．05）；DKK-1、PGSK-3β양성표체여궁경린암조직분화、FIGO림상분기급유무림파결전이현저상관（P＜0．05）；PGSK-3β단백표체량CIN Ⅰ、CINⅡ～Ⅲ급궁경린암조직명현고우만성궁경염조직（P＜0．05）；CINⅠ중PGSK-3β단백표체량명현고우궁경암조직（P＜0．05）。결론 DKK-1、GSK-3β、PGSK-3β표체여궁경린암적발생、발전밀절상관。
Objective To investigate the expression of DKK-1,GSK-3βand PGSK-3βin squamous cell carcinoma of the cervix( SCC) ,and its relationship with the development and clinicopathological features of SCC .Methods 25 patients with chro-nic cervicitis,29 patients with CIN and 41 patients with SCC were selected .The expression of DKK-1,GSK-3β,PGSK-3βwere de-tected by immunohistochemistry technique .Results Expression rates of DKK-1in chronic cervicitis and CIN were significantly higher than that of the SCC(P<0.05);expression rate of GSK-3βin chronic cervicitis was significantly higher than that of the SCC(P<0.05);expression rate of PGSK-3βin chronic cervicitis was significantly lower than that of the SCC (P<0.05);posi-tive expression rates of DKK-1and PGSK-3βwere related with tissue differentiation ,FIGO clinical stage and lymph node metasta-sis ( P<0.05);expression rates of PGSK-3βin CIN Ⅰ,CIN Ⅱ~Ⅲand SCC tissues were significantly higher than that of the chronic cervicitis(P<0.05);PGSK-3βexpression in CIN I was significantly higher than that of SCC tissue (P<0.05).Conclu-sion There is a close correlation between DKK-1,GSK-3β,PGSK-3βexpression and the development of SCC .