CAJ | 학술논문

目的：利用320排容积CT对胰腺癌患者进行全胰腺灌注分析，探讨胰腺癌病灶与其周围正常胰腺组织灌注特征。方法利用320排动态容积CT对25例胰腺癌患者进行全胰腺灌注扫描，测量并比较胰腺癌及周围相对正常胰腺组织的血流量(AF)、达峰时间(TTP)，对比分析病灶与周围组织的灌注差异。并统计身体质量指数(BMI)为22．0~24．0kg/m2时的放射剂量。结果胰腺癌病灶AF(49．95±19．29)(ml/min/100ml)明显低于周围正常胰腺组织[正常胰头：(134．18±35．39)；正常胰体：(138．81±51．72)；正常胰尾：(137．39±43．60)；胰腺癌TTP(50．80±4．81)s较周围正常胰腺组织(正常胰头：(21．35±5．51)；正常胰体：(21．99±7．07)；正常胰尾：(23．11±7．30)]延长，差异有统计学意义(P<0．05)。而正常胰腺组织头、体、尾部组间AF及TTP无统计学差异(P>0．05)。统计身体质量指数(BMI)为22．0~24．0kg/m2时放射剂量约为(18．6±2．4)mSv。结论320排动态容积CT胰腺灌注成像能够准确反映出胰腺癌及周围正常胰腺组织的血流灌注特点，在临床上对胰腺癌的诊断与治疗评估具有重要价值。
목적：이용320배용적CT대이선암환자진행전이선관주분석，탐토이선암병조여기주위정상이선조직관주특정。방법이용320배동태용적CT대25례이선암환자진행전이선관주소묘，측량병비교이선암급주위상대정상이선조직적혈류량(AF)、체봉시간(TTP)，대비분석병조여주위조직적관주차이。병통계신체질량지수(BMI)위22．0~24．0kg/m2시적방사제량。결과이선암병조AF(49．95±19．29)(ml/min/100ml)명현저우주위정상이선조직[정상이두：(134．18±35．39)；정상이체：(138．81±51．72)；정상이미：(137．39±43．60)；이선암TTP(50．80±4．81)s교주위정상이선조직(정상이두：(21．35±5．51)；정상이체：(21．99±7．07)；정상이미：(23．11±7．30)]연장，차이유통계학의의(P<0．05)。이정상이선조직두、체、미부조간AF급TTP무통계학차이(P>0．05)。통계신체질량지수(BMI)위22．0~24．0kg/m2시방사제량약위(18．6±2．4)mSv。결론320배동태용적CT이선관주성상능구준학반영출이선암급주위정상이선조직적혈류관주특점，재림상상대이선암적진단여치료평고구유중요개치。
Objective To study the value of perfusion imaging with 320-slice CT in diagnosis of pancreatic cancer and compare the perfusion parameters between pancreatic cancer and normal tissue in the same patient. Methods 25 patients with pancreatic cancer underwent CT perfusion on a 320-slice CT of Toshiba Aquilion one body perfusion software and the perfusion characteristic parameters( including AF,TTP) were compared. Results Pancreatic cancer showed higher TTP and lower AF com-pared with those of normal tissue in the same patient(P<0. 05). Conclusion 320-slice CT perfusion is a feasible technique to assess pancreatic blood perfusion. Comparison of perfusion parameters of pancreatic cancer and normal tissue of the same patient can be a good option in the diagnosis of pancreatic cancer. Permeability can assess the degree of blood vessels destruction.