临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
8期
747-751
,共5页
于万涛(综述)%王朝霞(审校)
于萬濤(綜述)%王朝霞(審校)
우만도(종술)%왕조하(심교)
miR-100%肿瘤%致癌基因%抑癌基因%靶基因
miR-100%腫瘤%緻癌基因%抑癌基因%靶基因
miR-100%종류%치암기인%억암기인%파기인
MiR-100%Tumor%Oncogene%Tumor suppressor gene%Target gene
miR-100既可表现出致癌基因的作用，又可表现出抑癌基因的作用，其不仅在多种肿瘤（宫颈癌、前列腺癌、膀胱癌和肺癌等）的发生、发展中发挥重要作用，而且还可增加肿瘤细胞对化疗药物的敏感性。 miR-100有望成为肿瘤治疗的新靶点及预测预后的新分子标记。本文结合国内外最新报道对miR-100与肿瘤相关性的研究进展作一综述。
miR-100既可錶現齣緻癌基因的作用，又可錶現齣抑癌基因的作用，其不僅在多種腫瘤（宮頸癌、前列腺癌、膀胱癌和肺癌等）的髮生、髮展中髮揮重要作用，而且還可增加腫瘤細胞對化療藥物的敏感性。 miR-100有望成為腫瘤治療的新靶點及預測預後的新分子標記。本文結閤國內外最新報道對miR-100與腫瘤相關性的研究進展作一綜述。
miR-100기가표현출치암기인적작용，우가표현출억암기인적작용，기불부재다충종류（궁경암、전렬선암、방광암화폐암등）적발생、발전중발휘중요작용，이차환가증가종류세포대화료약물적민감성。 miR-100유망성위종류치료적신파점급예측예후적신분자표기。본문결합국내외최신보도대miR-100여종류상관성적연구진전작일종술。
Recent studies have shown that miR-100 can act as oncogene or tumor suppressor gene in different tumors. It not only plays an important role in the development and progression of a variety of tumor types( cervical cancer, prostate cancer, bladder cancer, lung cancer, etc) , but also can resensitize tumor cell towards chemotherapeutic drugs. miR-100 is expected to become a new target for cancer treatment and a new molecular marker for prognostic predictors. In this review, we summarize the latest progresses, both domestic and overseas, in the roles of miR-100 in the tumor development.
