CAJ | 학술논문

支气管哮喘的气道重塑是气道炎症反复作用的结果，白三烯是气道重塑中的重要炎症介质之一。影响气道重塑的因素较多，近年来Th17细胞和CD4+CD25+调节性T细胞(CD4+CD25+treg细胞)在气道重塑中的作用日益受到重视。白三烯受体拮抗剂是治疗哮喘的有效药物，能在一定程度上抑制气道重塑，但其作用机制及对Th17细胞/CD4+CD25+treg细胞表达的影响机制尚不十分清楚。因此，阐明Th17细胞/CD4+CD25+treg细胞平衡在气道重塑中的表达变化、白三烯受体拮抗剂干预气道重塑的具体作用途径和生物效应及对Th17细胞/CD4+CD25+treg细胞表达的影响，将为以后哮喘患儿的预防和治疗提供新的靶点。
지기관효천적기도중소시기도염증반복작용적결과，백삼희시기도중소중적중요염증개질지일。영향기도중소적인소교다，근년래Th17세포화CD4+CD25+조절성T세포(CD4+CD25+treg세포)재기도중소중적작용일익수도중시。백삼희수체길항제시치료효천적유효약물，능재일정정도상억제기도중소，단기작용궤제급대Th17세포/CD4+CD25+treg세포표체적영향궤제상불십분청초。인차，천명Th17세포/CD4+CD25+treg세포평형재기도중소중적표체변화、백삼희수체길항제간예기도중소적구체작용도경화생물효응급대Th17세포/CD4+CD25+treg세포표체적영향，장위이후효천환인적예방화치료제공신적파점。
The airway remodeling of bronchial asthma is the result of repeated airway inlfammation. Its occurrence is a complex process involving many cytokines, inlfammatory mediators and associated cellular components, of which leukotrienes are important mediators of inlfammation in the airway remodeling. Many factors inlfuence Airway remodeling. In recent years, effects of Th17 cells and CD4+CD25+regulatory T cells (CD4+CD25+treg cells) on airway remodeling is growing in importance. Leukotriene receptor antagonist is an effective drug in the treatment of asthma and can suppress airway remodeling. But the exact mechanisms and its impact on the proportion of Th17 cells/CD4+CD25+treg cells is not yet clear. Therefore, the clariifcation of the changes of Th17 cells/CD4+CD25+treg cells expression in airway remodeling and the speciifc pathways, biological effects, inlfuence of the proportion of Th17 cells/CD4+CD25+treg cells expression after leukotriene receptor antagonist intervene can provide a new target for prevention and the treatment of asthma in the future.