临床儿科杂志
臨床兒科雜誌
림상인과잡지
2014年
8期
760-762
,共3页
川崎病%CD40基因%多态性%临床特征
川崎病%CD40基因%多態性%臨床特徵
천기병%CD40기인%다태성%림상특정
Kawasaki disease%CD40 gene%polymorphism%clinical characteristic
目的：探讨CD40基因的SNP位点rs1569723多态性与川崎病(KD)以及临床特点的相关性。方法采取病例对照研究方法，分别选取179例KD患儿和197例健康儿童作为研究对象。利用PCR-RFLP的方法测定SNP位点多态性分布；超声心动图检测动脉损伤。结果 KD组的SNP位点(rs1569723)的3种基因型(AA、AC、CC)分布与对照组相比，差异有统计学意义(P=0.044)，且A风险等位基因与KD易感性显著相关(OR=1.51，95%CI：1.10-2.07，P=0.012)。SNP位点(rs1569723)3种基因型(AA、AC、CC)，皮疹及淋巴结肿大的发生概率均以AA基因型的发生概率为最高，CC基因型最低，差异均有统计学意义(P=0.041、0.010)。SNP位点(rs1569723)多态性与结膜充血、口腔黏膜病变、手足水肿、冠状动脉损伤无关(P均>0.05)。结论 CD40基因SNP位点(rs1569723)与KD的易感性相关，A等位基因为风险因子；且该SNP位点可能与KD患儿的皮疹以及淋巴结肿大等特征相关。
目的：探討CD40基因的SNP位點rs1569723多態性與川崎病(KD)以及臨床特點的相關性。方法採取病例對照研究方法，分彆選取179例KD患兒和197例健康兒童作為研究對象。利用PCR-RFLP的方法測定SNP位點多態性分佈；超聲心動圖檢測動脈損傷。結果 KD組的SNP位點(rs1569723)的3種基因型(AA、AC、CC)分佈與對照組相比，差異有統計學意義(P=0.044)，且A風險等位基因與KD易感性顯著相關(OR=1.51，95%CI：1.10-2.07，P=0.012)。SNP位點(rs1569723)3種基因型(AA、AC、CC)，皮疹及淋巴結腫大的髮生概率均以AA基因型的髮生概率為最高，CC基因型最低，差異均有統計學意義(P=0.041、0.010)。SNP位點(rs1569723)多態性與結膜充血、口腔黏膜病變、手足水腫、冠狀動脈損傷無關(P均>0.05)。結論 CD40基因SNP位點(rs1569723)與KD的易感性相關，A等位基因為風險因子；且該SNP位點可能與KD患兒的皮疹以及淋巴結腫大等特徵相關。
목적：탐토CD40기인적SNP위점rs1569723다태성여천기병(KD)이급림상특점적상관성。방법채취병례대조연구방법，분별선취179례KD환인화197례건강인동작위연구대상。이용PCR-RFLP적방법측정SNP위점다태성분포；초성심동도검측동맥손상。결과 KD조적SNP위점(rs1569723)적3충기인형(AA、AC、CC)분포여대조조상비，차이유통계학의의(P=0.044)，차A풍험등위기인여KD역감성현저상관(OR=1.51，95%CI：1.10-2.07，P=0.012)。SNP위점(rs1569723)3충기인형(AA、AC、CC)，피진급림파결종대적발생개솔균이AA기인형적발생개솔위최고，CC기인형최저，차이균유통계학의의(P=0.041、0.010)。SNP위점(rs1569723)다태성여결막충혈、구강점막병변、수족수종、관상동맥손상무관(P균>0.05)。결론 CD40기인SNP위점(rs1569723)여KD적역감성상관，A등위기인위풍험인자；차해SNP위점가능여KD환인적피진이급림파결종대등특정상관。
Objective To investigate the association between nucleotide polymorphisms (rs1569723 in CD40 gene) and clinical characteristics in Kawasaki disease (KD) in Han Chinese children. Methods A case-control study was performed,and 179 children with KD and other 197 normal children served as controls were included. The SNP genotypes were detected using PCR-RFLP, and all data were analyzed by SPSS 19.0. Results It was found that the SNP (rs1569723) was associated with KD (P=0.048), and the frequency of A allele in KD group was higher than that in control group (OR=1.505, 95%CI:1.095-2.070, P=0.012). SNP genotypes were associated with rash and lymphadenopathy (P=0.041, 0.047), but not associated with conjunctival hyperemia, hand-foot edema, oral mucosa lesions, and coronary artery lesion (P=0.688,0.758, 0.557, 0.552). Conclusions Genotypes of SNP (rs1569723) were associated with KD susceptibility, and A-allele is a risk allele. The SNP loci might be associated with rash and lymphadenopathy in KD in Han Chinese.
