CAJ | 학술논문

目的：分析儿童支气管哮喘与母孕期及新生儿期各因素的相关性，为疾病预防提供依据。方法对已确诊为支气管哮喘的162例患儿以及213名正常儿童进行回顾性调查，包括一般情况，母亲围孕期情况(产次、孕早期发热、妊娠高血压综合征、妊娠糖尿病、孕早期服药史)，新生儿情况(出生时体表缺陷、窒息、胎盘粗糙、出生体质量、胎数、胎龄、剖宫产)。结果支气管哮喘儿童与对照儿童，母亲孕早期发热、妊娠高血压综合征、孕早期服药、胎盘粗糙、窒息、出生体质量、早产、剖宫产的差异均有统计学意义(P<0.05)；多因素Logistic回归分析发现，母亲孕早期发热(OR=9.43，95%CI：3.08~28.82)、胎盘粗糙(OR=2.15，95%CI：1.29~3.59)、早产(OR=5.16，95%CI：1.53~17.39)、剖宫产(OR=4.05，95%CI：2.40~6.86)均为儿童哮喘的独立危险因素。结论母亲孕早期发热、胎盘粗糙、早产、剖宫产可能与儿童支气管哮喘发生相关。
목적：분석인동지기관효천여모잉기급신생인기각인소적상관성，위질병예방제공의거。방법대이학진위지기관효천적162례환인이급213명정상인동진행회고성조사，포괄일반정황，모친위잉기정황(산차、잉조기발열、임신고혈압종합정、임신당뇨병、잉조기복약사)，신생인정황(출생시체표결함、질식、태반조조、출생체질량、태수、태령、부궁산)。결과지기관효천인동여대조인동，모친잉조기발열、임신고혈압종합정、잉조기복약、태반조조、질식、출생체질량、조산、부궁산적차이균유통계학의의(P<0.05)；다인소Logistic회귀분석발현，모친잉조기발열(OR=9.43，95%CI：3.08~28.82)、태반조조(OR=2.15，95%CI：1.29~3.59)、조산(OR=5.16，95%CI：1.53~17.39)、부궁산(OR=4.05，95%CI：2.40~6.86)균위인동효천적독립위험인소。결론모친잉조기발열、태반조조、조산、부궁산가능여인동지기관효천발생상관。
Objective To explore the relationship between childhood asthma and pregnant and neonatal risk factors, thus provide evidence for early prevention of childhood asthma. Methods 162 children diagnosed asthma and 213 healthy children in pediatric outpatient and the inpatient services of our hospital who was born and living in Baotou city were retrospectively analyzed. The pregnancy related factors (parity, fever during pregnancy, pregnancy-induced hypertension syndrome, gestational diabetes mellitus, history of overdose in early-pregnancy) and the neonatal period related factors (surface defects, asphyxia, rough placenta, birth weight, number of fetus during this pregnancy, gestational age, premature birth, cesarean section) were investigated. The sex and age showed no signiifcance between childhood asthma and control group. Results Eight pregnant and neonatal factors (fever during pregnancy, pregnancy-induced hypertension syndrome, history of overdose in early-pregnancy, surface defects, asphyxia, rough placenta, birth weight, premature birth, cesarean section) showed signiifcant difference between the two groups (P<0.05). Multifactor regression analysis found fever during pregnancy (OR=9.43, 95%CI:3.08~28.82), rough placenta (OR=2.15, 95%CI:1.29~3.59), premature birth (OR=5.16, 95%CI:1.53~17.39) and cesarean section (OR=4.05, 95%CI:2.40~6.86)are independent risk factors for childhood asthma. Conclusions Fever during pregnancy, abnormal placenta;premature birth and cesarean section are likely risk factors of childhood asthma.