CAJ | 학술논문

目的：建立长沙地区健康成年人血清中胃蛋白酶原（PG）的参考值范围，并探讨其分布规律及相关影响因素。方法利用乳胶增强免疫比浊法对长沙地区1279例健康人进行血清中 PGⅠ和 PGⅡ浓度的测定，并计算 PGⅠ/PGⅡ。结果1279例健康成年居民血清中PGⅠ、PGⅡ和PGⅠ/PGⅡ均呈偏态分布。男性血清PGⅠ浓度为62．0 ng/mL、PGⅠ/PGⅡ为4．3，女性分别为59．4 ng/mL、4．1，均低于男性，差异有统计学意义（P＜0．05），PGⅡ的浓度与年龄呈正相关（r＝0．278，P＜0．01），PGⅠ/PGⅡ值与年龄呈负相关（r＝-0．173，P＜0．01）。男性健康成年居民血清中PGⅠ、PGⅡ和PGⅠ/PGⅡ的95％正常参考范围分别为：≥56．8 ng/mL、≤22．6 ng/mL、≥3．3；女性健康成年居民 PGⅠ、PGⅡ和 PGⅠ/PGⅡ的95％正常参考范围分别为：≥51．4 ng/mL、≤23．1 ng/mL、≥3．0。结论长沙地区居民血清PG水平呈明显偏态分布，受性别、年龄影响，建立当地的血清PG参考范围有助于临床对胃相关疾病的筛查与诊断。
목적：건립장사지구건강성년인혈청중위단백매원（PG）적삼고치범위，병탐토기분포규률급상관영향인소。방법이용유효증강면역비탁법대장사지구1279례건강인진행혈청중 PGⅠ화 PGⅡ농도적측정，병계산 PGⅠ/PGⅡ。결과1279례건강성년거민혈청중PGⅠ、PGⅡ화PGⅠ/PGⅡ균정편태분포。남성혈청PGⅠ농도위62．0 ng/mL、PGⅠ/PGⅡ위4．3，녀성분별위59．4 ng/mL、4．1，균저우남성，차이유통계학의의（P＜0．05），PGⅡ적농도여년령정정상관（r＝0．278，P＜0．01），PGⅠ/PGⅡ치여년령정부상관（r＝-0．173，P＜0．01）。남성건강성년거민혈청중PGⅠ、PGⅡ화PGⅠ/PGⅡ적95％정상삼고범위분별위：≥56．8 ng/mL、≤22．6 ng/mL、≥3．3；녀성건강성년거민 PGⅠ、PGⅡ화 PGⅠ/PGⅡ적95％정상삼고범위분별위：≥51．4 ng/mL、≤23．1 ng/mL、≥3．0。결론장사지구거민혈청PG수평정명현편태분포，수성별、년령영향，건립당지적혈청PG삼고범위유조우림상대위상관질병적사사여진단。
Objective To establish the reference intervals of serum pepsinogen(PG)in healthy adults in Changsha area,and to explore their distribution as well as related factors.Methods Serum PGⅠand PGⅡ levels were determined by a latex-enhanced turbidimetric immunoassay method in 1 279 subjects from Changsha area.Then PGⅠ/PGⅡ was calculated.Results The PGⅠ, PGⅡ and PGⅠ/PGⅡ levels of 1 279 healthy adult residents showed a skew distribution.The levels of serum PGⅠand PGⅠ/PGⅡ in males were 62.0 ng/mL and 4.3,which in females were 59.4 ng/mL and 4.1,significantly lower than those in males(P<0.05).Age was significantly positive correlated with serum concentrations of PGⅡ(r= 0.278,P<0.01),and was negative correla-ted with PGⅠ/PGⅡratio(r= -0.173,P<0.01).The normal reference ranges of serum PGⅠ,PGⅡ and PGⅠ/PGⅡ in males were≥56.8 ng/mL,≤22.6 ng/mL,and ≥3.3,respectively,and in females were ≥51.4 ng/mL,≤23.1 ng/mL,and ≥3.0,respec-tively.Conclusion The serum PG levels of healthy adult residents significantly show skew distributions in Changsha area,which are affected by gender and age.The establishment of reference intervals of PG contributes to clinical screening and diagnosis of gas-tric-related deseases.