CAJ | 학술논문

目的：探讨检测血清降钙素原（PCT）、超敏C反应蛋白（hs-CRP）、白细胞计数（WBC）在慢性阻塞性肺疾病急性加重（AECOPD）患者诊疗中的意义。方法选择45例AECOPD患者（AECOPD组）及50例慢性阻塞性肺疾病（COPD）稳定期患者（COPD组），分别测定其 PCT、hs-CRP 和 WBC。结果治疗前 AECOPD 组的 PCT、hs-CRP 分别为（3．32±1．81）ng/mL 和（22．36±5．03）mg/L，明显高于COPD组，差异有统计学意义（P＜0．01）。AECOPD组的PCT、hs-CRP 阳性率诊断为68．9％和60．0％，均高于COPD组，差异有统计学意义（P＜0．01）。AECOPD患者经抗菌药物治疗后PCT、hs-CRP、WBC较治疗前显著降低，差异有统计学意义（P＜0．01）。结论在AECOPD患者中，PCT和hs-CRP是较好的诊断指标。
목적：탐토검측혈청강개소원（PCT）、초민C반응단백（hs-CRP）、백세포계수（WBC）재만성조새성폐질병급성가중（AECOPD）환자진료중적의의。방법선택45례AECOPD환자（AECOPD조）급50례만성조새성폐질병（COPD）은정기환자（COPD조），분별측정기 PCT、hs-CRP 화 WBC。결과치료전 AECOPD 조적 PCT、hs-CRP 분별위（3．32±1．81）ng/mL 화（22．36±5．03）mg/L，명현고우COPD조，차이유통계학의의（P＜0．01）。AECOPD조적PCT、hs-CRP 양성솔진단위68．9％화60．0％，균고우COPD조，차이유통계학의의（P＜0．01）。AECOPD환자경항균약물치료후PCT、hs-CRP、WBC교치료전현저강저，차이유통계학의의（P＜0．01）。결론재AECOPD환자중，PCT화hs-CRP시교호적진단지표。
Objective To evaluate the clinical significance of detection of serum procalcitonin(PCT),high sensitivity-C-reactive protein(hs-CRP)and leukocyte in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients.Methods 45 patients with AECOPD and 50 patients(AECOPD group)with chronic obstructive pulmonary disease(COPD)in slationary phase (COPD group)were selected,and their serum levels of PCT,hs-CRP and leukocyte were tested.Results Before treatment,the con-centrations of PCT and hs-CRP were (3.32±1.81)ng/mL and (22.36±5.03)mg/L in AECOPD group respectively.They were significantly higher than those in COPD group with statistical differences(P<0.01).The positive predictive value of PCT and hs-CRP was 68.9% and 60.0% in AECOPD group respectively,which were significantly higher than those in COPD group(P<0.01).After antibiotic treatment,the leukocyte,PCT,and hs-CRP levels in AECOPD group were significantly lower than those be-fore treatment(P< 0.01).Conclusion In AECOPD patients,PCT and hs-CRP are good diagnostic indexes.