CAJ | 학술논문

目的确定瑞芬太尼抑制维吾尔族患者拔管反应的的半数有效浓度(EC50).方法全身麻醉下行择期手术的维吾尔族患者,年龄18 ～ 60岁,性别不限,ASA分级Ⅰ或Ⅱ级.手术完毕后按序贯法TCI瑞芬太尼直到拔除气管导管.初始瑞芬太尼Cp为2 ng/ml,若拔管期间MAP和/或HR升高幅度＞术毕水平的15％且持续时间＞15s为阳性,则下一例患者Cp增加一梯度,反之,降低一梯度,浓度梯度比值为1.1.采用Probit法计算瑞芬太尼抑制维吾尔族患者拔管反应的EC50及其95％可信区间(CI).结果共纳入28例患者.瑞芬太尼抑制维吾尔族患者拔管反应的EC50及其95％CI分别为1.75 ng/ml和1.45 ～ 2.01 ng/ml.结论瑞芬太尼抑制维吾尔族患者拔管反应的EC50为1.75ng/ml.
목적 학정서분태니억제유오이족환자발관반응적적반수유효농도(EC50).방법 전신마취하행택기수술적유오이족환자,년령18 ～ 60세,성별불한,ASA분급Ⅰ혹Ⅱ급.수술완필후안서관법TCI서분태니직도발제기관도관.초시서분태니Cp위2 ng/ml,약발관기간MAP화/혹HR승고폭도＞술필수평적15％차지속시간＞15s위양성,칙하일례환자Cp증가일제도,반지,강저일제도,농도제도비치위1.1.채용Probit법계산서분태니억제유오이족환자발관반응적EC50급기95％가신구간(CI).결과 공납입28례환자.서분태니억제유오이족환자발관반응적EC50급기95％CI분별위1.75 ng/ml화1.45 ～ 2.01 ng/ml.결론 서분태니억제유오이족환자발관반응적EC50위1.75ng/ml.
Objective To determine the median effective concentration (EC50) of remifentanil inhibiting responses to tracheal extubation in patients of Uygur nationality.Methods The patients of Uygur nationality,aged 18-60 yr,of ASA physical status Ⅰ or [Ⅱ,scheduled for elective surgery,were enrolled in this study.After the end of surgery,remifentanil was given by target-controlled infusion until tracheal extubation.The initial target plasma concentration (Cp) of remifentanil was 2.0 ng/ml.The response was defined as positive when MAP and/or HR increased by ＞ 15％ of the level at the end of operation and the duration ＞ 15 s during extubation.Each time the target Cp increased/decreased if the cardiovascular response was positive or negative.The ratio between the two successive concentrations was 1.1.The EC50 and 95 ％ confidence interval of remifentanil blunting responses to extubation was calculated by Probit method.Results Twenty-eight patients completed the study.The EC50 and 95 ％ confidence interval of remifentanil required for inhibiting the responses to extubation was 1.75 ng/ml and 1.45-2.01 ng/ml.Conclusion The EC50 of remifentanil inhibiting the responses to tracheal extubation is 1.75 ng/ ml in patients of Uygur nationality.