中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
8期
1185-1186
,共2页
感染性疾病%降钙素原%C反应蛋白质
感染性疾病%降鈣素原%C反應蛋白質
감염성질병%강개소원%C반응단백질
Inflammatory disease%Serum procalcitonin%C-reactive protein
目的 探讨血清降钙素原(PCT)和超敏C反应蛋白(hsCRP)用于感染性疾病早期诊断的价值.方法 随机采集79例感染性疾病患者血清,其中细菌性感染54例,非细菌性感染25例,采用免疫荧光法测PCT;采用免疫比浊法测hsCRP.结果 细菌性感染患者PCT阳性率显著高于非细菌感染患者(x2=48.337,P＜0.01),敏感性92.5％,特异性88.0％;细菌性感染患者hsCRP阳性率显著高于非细菌感染患者(x2=22.347,P＜0.01),敏感性88.9％,特异性56.0％,阳性预测值(88.9％)与阴性预测值(70.0％)均低于PCT(阳性预测值94.3％和阴性预测值84.6％).结论 PCT在细菌性感染患者血清中明显升高,具有较高的敏感性和特异性,可作为临床新的炎症标志物,有助于病情的早期评估、预后评价及疗效观察.
目的 探討血清降鈣素原(PCT)和超敏C反應蛋白(hsCRP)用于感染性疾病早期診斷的價值.方法 隨機採集79例感染性疾病患者血清,其中細菌性感染54例,非細菌性感染25例,採用免疫熒光法測PCT;採用免疫比濁法測hsCRP.結果 細菌性感染患者PCT暘性率顯著高于非細菌感染患者(x2=48.337,P＜0.01),敏感性92.5％,特異性88.0％;細菌性感染患者hsCRP暘性率顯著高于非細菌感染患者(x2=22.347,P＜0.01),敏感性88.9％,特異性56.0％,暘性預測值(88.9％)與陰性預測值(70.0％)均低于PCT(暘性預測值94.3％和陰性預測值84.6％).結論 PCT在細菌性感染患者血清中明顯升高,具有較高的敏感性和特異性,可作為臨床新的炎癥標誌物,有助于病情的早期評估、預後評價及療效觀察.
목적 탐토혈청강개소원(PCT)화초민C반응단백(hsCRP)용우감염성질병조기진단적개치.방법 수궤채집79례감염성질병환자혈청,기중세균성감염54례,비세균성감염25례,채용면역형광법측PCT;채용면역비탁법측hsCRP.결과 세균성감염환자PCT양성솔현저고우비세균감염환자(x2=48.337,P＜0.01),민감성92.5％,특이성88.0％;세균성감염환자hsCRP양성솔현저고우비세균감염환자(x2=22.347,P＜0.01),민감성88.9％,특이성56.0％,양성예측치(88.9％)여음성예측치(70.0％)균저우PCT(양성예측치94.3％화음성예측치84.6％).결론 PCT재세균성감염환자혈청중명현승고,구유교고적민감성화특이성,가작위림상신적염증표지물,유조우병정적조기평고、예후평개급료효관찰.
Objective To explore the clinical applications of the PCT and hs-CRP in inflammatory diseases.Methods The sera of 79 infectious patients were randomly collected.54 samples were bacterial infectious patients,25 samples were nonbacterial infectious patients.The serum levels of PCT and hsCRP in 79 infectious cases were detected by immune fluorescence and Immunoturbidimetry respectively.Results The positive rate of PCT in bacterial infectious patients were much higher than that in nonbacterial infectious patients (x2 =48.337,P ＜ 0.01),and the sensitivity was 92.5％,the specificity was 88.0％ ;The positive rate of hs-CRP in bacterial infectious patients were much higher than that in nonbacterial infectious patients (x2 =22.347,P ＜ 0.01),and the specificity was 88.9％,the specificity was 56.0％.The positive predictive value (88.9％) and negative predictive value (70.0％) of hs-CRP were lower than those of PCT (positive predictive values of 94.3％ and negative predictive value of 84.6％).Conclusion Theserum levels of PCT in inflammatory diseases were significantly increased with an high sensitivity and high specificity.Thus,it may be used as a new marker of inflammatory,which can be helpful in the early evaluation of infectious disease and the observation of curative efficacy.
