CAJ | 학술논문

微小RNA(microRNA,miRNA)是内源性非编码单链小分子RNA,可通过与mRNA的3'-非编码区特异性结合引发转录后基因沉默效应来调节mRNA表达.最近的研究显示,miRNA广泛参与了动脉粥样硬化、脑缺血缺氧耐受、脑水肿、神经细胞死亡等多种病理生理学过程,提示miRNA可能作为缺血性卒中早期诊断的生物学标记物以及早期治疗的生物学靶标.文章对miRNA的生物学特性及其与缺血性卒中的关系和作用机制进行了综述,以期为miRNA在缺血性卒中的诊断和治疗方面提供新的依据和思路.
미소RNA(microRNA,miRNA)시내원성비편마단련소분자RNA,가통과여mRNA적3'-비편마구특이성결합인발전록후기인침묵효응래조절mRNA표체.최근적연구현시,miRNA엄범삼여료동맥죽양경화、뇌결혈결양내수、뇌수종、신경세포사망등다충병리생이학과정,제시miRNA가능작위결혈성졸중조기진단적생물학표기물이급조기치료적생물학파표.문장대miRNA적생물학특성급기여결혈성졸중적관계화작용궤제진행료종술,이기위miRNA재결혈성졸중적진단화치료방면제공신적의거화사로.
MicroRNAs (miRNAs) are endogenous,small,non-coding,single-stranded RNA molecules,which can specifically bind to the 3'-terminal non-coding regions of mRNA chain to induce posttranscriptional gene silencing effect and regulate the expression of mRNA.Recent studies have shown that miRNAs have extensively involved in various pathophysiological processes,including atherosclerosis,cerebral ischemia and hypoxia tolerance,cerebral edema,neuronal cell death,suggesting miRNAs may be used as biological markers of the early diagnosis of ischemic stroke and the biological target of early treatment.This article reviews the biological characteristics of miRNAs,its relationship with ischemic stroke and mechanism of action in order to provide new evidence and ideas for miRNAs in the diagnosis and treatment of ischemic stroke.