CAJ | 학술논문

目的利用Meta分析评价益生菌对小年龄儿童湿疹的治疗效果。方法按照系统评价的要求全面检索PubMed、Medline、EMBASE等文献数据库，根据临床和统计标准采用Cochrane协作网提供的Rev-Man 5.2软件进行合并分析。结果共检索到85篇文献，符合纳入标准的有5项临床随机对照研究，共计528例湿疹病例进入Meta分析。纳入分析的5项研究的异质性检验具有临床和统计学上的同质性（ P＝0.18，I2＝36％），用固定效应模型进行Meta分析，结果显示益生菌对小年龄儿童湿疹治疗前后SCORAD指数均数的合并统计值及95％的可信区间为1.71（1.17～2.24），与对照组相比，添加益生菌并不能明显降低湿疹患儿的SCORAD指数。结论益生菌治疗小年龄儿童湿疹无明显疗效。
목적이용Meta분석평개익생균대소년령인동습진적치료효과。방법안조계통평개적요구전면검색PubMed、Medline、EMBASE등문헌수거고，근거림상화통계표준채용Cochrane협작망제공적Rev-Man 5.2연건진행합병분석。결과공검색도85편문헌，부합납입표준적유5항림상수궤대조연구，공계528례습진병례진입Meta분석。납입분석적5항연구적이질성검험구유림상화통계학상적동질성（ P＝0.18，I2＝36％），용고정효응모형진행Meta분석，결과현시익생균대소년령인동습진치료전후SCORAD지수균수적합병통계치급95％적가신구간위1.71（1.17～2.24），여대조조상비，첨가익생균병불능명현강저습진환인적SCORAD지수。결론익생균치료소년령인동습진무명현료효。
Objective To conduct a systematic review of whether administration of probiotics is effective to decrease the SCORAD of atopic dermatitis in infants and preschool children .Methods We searched PubMed , Medline,EMBASE from the beginning of databases to 2013.Tow independent researchers evaluated the included studies using Jaded.The meat-analysis was performed by Review Manager 5.2 software.Results 85 literatures were reviewed.A total of 5 clinical trials were incorporated ,which included 528 patients.The results of these five studies were consistent,with no heterogeneity between the different studies (P=0.18,I2 =36%).Thus the studies were analyzed with the fix effects model .Meta-analysis of data from these trials showed that administration of probiotics did not significantly decrease the SCORAD of atopic dermatitis in infants and preschool children ( mean difference 1.71;95%confidence interval 1.17-2.24 ) .Conclusion Administration of probiotics is not effective for the therapy of atopic dermatitis in infants and preschool children .