CAJ | 학술논문

目的测试人造主动脉弓覆膜支架在正常狗模型中进行主动脉弓部重建的可行性。方法支架系统由主体支架和两个分支支架共同构成。挑选10只成年德国牧羊犬作为手术置入支架的对象。通过术后短期内的恢复结果以及术后6个月的影像学检查来评估实验结果。结果手术支架在所有实验动物中均能顺利置入，手术成功率为90％。平均体外循环时间和深低温停循环时间分别为（83.9±8.56）min和（11.1±2.42）min。术后存活实验动物6个月内恢复良好，未见明显并发症。术后6个月影像学检查提示支架在位，形态正常，管腔通.。结论应用我们的新型支架结合手术方式进行正常犬主动脉弓部重建是安全可行的。如果用来治疗急性A型夹层患者，对比传统手术和腔内隔绝技术我们的新技术能给患者带来更大的益处。
목적측시인조주동맥궁복막지가재정상구모형중진행주동맥궁부중건적가행성。방법지가계통유주체지가화량개분지지가공동구성。도선10지성년덕국목양견작위수술치입지가적대상。통과술후단기내적회복결과이급술후6개월적영상학검사래평고실험결과。결과수술지가재소유실험동물중균능순리치입，수술성공솔위90％。평균체외순배시간화심저온정순배시간분별위（83.9±8.56）min화（11.1±2.42）min。술후존활실험동물6개월내회복량호，미견명현병발증。술후6개월영상학검사제시지가재위，형태정상，관강통.。결론응용아문적신형지가결합수술방식진행정상견주동맥궁부중건시안전가행적。여과용래치료급성A형협층환자，대비전통수술화강내격절기술아문적신기술능급환자대래경대적익처。
Objective To test the technical feasibility of an innovative hybrid strategy with our newly designed stent-grafts on reconstructing aortic arch in normal canine models .Methods The stent-graft system was composed of two parts:the main body and 2 branches were attached ,corresponding to the number of reconstructing cervical artery .10 adult hybrid dogs were operated with the new stent-graft procedure .The outcome was assessed by the short-term operative prognosis and imaging studies .Results All dogs were successfully implanted with the stent grafts.The technical success rate was 90%(9 of 10).Average time of cardiopulmonary bypass ,and deep hypothermic circulatory arrest was(83.9 ±8.56)min and(11.1 ±2.42)min,respectively.The dogs survived for 6 months without obvious cerebral ,visceral or limb ischaemia .Postoperative aortic imaging indicated that the main body and branches of the stent graft were fully open and in satisfactory position and location .Conclusion It is safety and feasible to reconstruct aortic arch of normal canine using the new stent-graft with open stent-grafting hybrid technique , and compared to conventional open surgical repair or endovascular repair , the patients who suffered from type A acute aortic dissection may get more benefits if they were treated with the new stent-graft.