检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2013年
19期
2560-2561
,共2页
胸腰椎骨折%静脉血栓栓塞%利伐沙班%低分子量肝素
胸腰椎骨摺%靜脈血栓栓塞%利伐沙班%低分子量肝素
흉요추골절%정맥혈전전새%리벌사반%저분자량간소
thoracolumbar fractures%venous thromboembolism%rivaroxaban%low molecular weight heparin
目的探讨利伐沙班对胸腰椎骨折患者术后预防静脉血栓栓塞症（VTE）的临床疗效及安全性。方法以喀什地区第一人民医院收治的胸腰椎骨折100例患者为研究对象，随机分为两组：试验组50例（术后服用利伐沙班）；对照组50例（皮下注射低分子量肝素）。在术前和术后14 d 进行随访，根据彩超观察 VTE 的发生情况。结果试验组术后 VTE 的发生率为8％低于对照组（18％，P＜0．05）；试验组总的出血事件发生率为6％（大出血1例，非大出血2例）稍微高于对照组总的4％（非大出血2例，无大出血，P ＞0．05）；试验组平均引流量[（365．6±181．4）mL]高于对照组[（300．7±108．2）mL ，P＜0．05]；术后10 d 比较两组患者凝血系统变化差异无统计学意义（P＞0．05）。结论应用利伐沙班预防胸腰椎骨折患者术后 VTE 安全、有效。
目的探討利伐沙班對胸腰椎骨摺患者術後預防靜脈血栓栓塞癥（VTE）的臨床療效及安全性。方法以喀什地區第一人民醫院收治的胸腰椎骨摺100例患者為研究對象，隨機分為兩組：試驗組50例（術後服用利伐沙班）；對照組50例（皮下註射低分子量肝素）。在術前和術後14 d 進行隨訪，根據綵超觀察 VTE 的髮生情況。結果試驗組術後 VTE 的髮生率為8％低于對照組（18％，P＜0．05）；試驗組總的齣血事件髮生率為6％（大齣血1例，非大齣血2例）稍微高于對照組總的4％（非大齣血2例，無大齣血，P ＞0．05）；試驗組平均引流量[（365．6±181．4）mL]高于對照組[（300．7±108．2）mL ，P＜0．05]；術後10 d 比較兩組患者凝血繫統變化差異無統計學意義（P＞0．05）。結論應用利伐沙班預防胸腰椎骨摺患者術後 VTE 安全、有效。
목적탐토리벌사반대흉요추골절환자술후예방정맥혈전전새증（VTE）적림상료효급안전성。방법이객십지구제일인민의원수치적흉요추골절100례환자위연구대상，수궤분위량조：시험조50례（술후복용리벌사반）；대조조50례（피하주사저분자량간소）。재술전화술후14 d 진행수방，근거채초관찰 VTE 적발생정황。결과시험조술후 VTE 적발생솔위8％저우대조조（18％，P＜0．05）；시험조총적출혈사건발생솔위6％（대출혈1례，비대출혈2례）초미고우대조조총적4％（비대출혈2례，무대출혈，P ＞0．05）；시험조평균인류량[（365．6±181．4）mL]고우대조조[（300．7±108．2）mL ，P＜0．05]；술후10 d 비교량조환자응혈계통변화차이무통계학의의（P＞0．05）。결론응용리벌사반예방흉요추골절환자술후 VTE 안전、유효。
Objective To study the efficacy and safety of rivaroxaban for the prevention of post-operative ve-nous thromboembolism (VTE) in patients with thoracolumbar fractures .Methods 100 patients with thoracolumbar fractures were enrolled and divided into experiment group (50 cases) ,receiving post-operative treatment of rivaroxa-ban ,and control group (50 cases) ,receiving subcutaneous injection of low molecular weight heparin .The incidence of VTE was compared before and 14 days after surgery within and between the two groups .Results The incidence of VTE in experiment group was 8% ,lower than the 18% in control group (P< 0 .05) .The incidence of bleeding events in the experiment group was 6% ,including 1 case of hemorrhoea and 2 cases of non-hemorrhoea ,which was slightly higher than the incidence of 4% in control group ,including 2 cases of non-hemorrhoea ,but the difference was not sta-tistically significant (P> 0 .05) .The drainage volume of observation group was (365 .6 ± 181 .4)mL ,higher than the (300 .7 ± 108 .2)mL of control group (P< 0 .05) .The difference of blood coagulation system indicators between the two groups ,detected at 10 days after surgery ,was not statistically different (P > 0 .05) .Conclusion Rivaroxaban could be effective and safe for the prevention of post-operative VTE in patients with thoracolumbar fractures .
