CAJ | 학술논문

目的探讨2型糖尿病（T2DM ）患者血糖控制水平与并发糖尿病肾病风险的关系。方法根据糖化血红蛋白（HbA1c）的含量将2型糖尿病患者分成血糖控制良好组（HbA1c ≤7．0％，n ＝72）、血糖控制不佳组（HbA1c ＞7．0％，n＝32），分别检测血清中胱抑素 C（Cys C）、肌酐（Cr）、尿素（Urea）、超敏 C 反应蛋白（hs-CRP）和尿液中视黄醇结合蛋白（U-RBP）、尿微量清蛋白（U-mAlb）等项目。结果糖尿病各组血清 Cys C 、hs-CRP 、U-RBP和 U-mAlb 与对照组比较均升高（P＜0．05或 P＜0．01），并且患者血糖控制水平越差，Cys C 、hs-CRP 、U-RBP 和 U-mAlb 升高幅度越大。结论 T2DM 患者 HbA1c 水平越高，血糖控制越差，并发糖尿病肾病的风险就越高。因此，控制好血糖对预防或延缓 T2DM 患者并发糖尿病肾病具有重要意义。
목적탐토2형당뇨병（T2DM ）환자혈당공제수평여병발당뇨병신병풍험적관계。방법근거당화혈홍단백（HbA1c）적함량장2형당뇨병환자분성혈당공제량호조（HbA1c ≤7．0％，n ＝72）、혈당공제불가조（HbA1c ＞7．0％，n＝32），분별검측혈청중광억소 C（Cys C）、기항（Cr）、뇨소（Urea）、초민 C 반응단백（hs-CRP）화뇨액중시황순결합단백（U-RBP）、뇨미량청단백（U-mAlb）등항목。결과당뇨병각조혈청 Cys C 、hs-CRP 、U-RBP화 U-mAlb 여대조조비교균승고（P＜0．05혹 P＜0．01），병차환자혈당공제수평월차，Cys C 、hs-CRP 、U-RBP 화 U-mAlb 승고폭도월대。결론 T2DM 환자 HbA1c 수평월고，혈당공제월차，병발당뇨병신병적풍험취월고。인차，공제호혈당대예방혹연완 T2DM 환자병발당뇨병신병구유중요의의。
Objective To investigate the relationship between the control of blood glucose level and the risk of diabetic nephropathy (DN ) in patients with type 2 diabetic mellitus (T2DM ) .Methods According to the level of glycosylated hemoglobin A1c (HbA1c) ,T2DM patients were assigned into 2 groups ,including tight blood glucose control group (HbA1c ≤ 7 .0% ,n= 72) and loose blood glucose control group (HbA1c > 7 .0% ,n= 32) .Serum levels of cystatin C (Cys C) ,creatine(Cr) ,urea ,high sensitive C-reactive protein (hs-CRP) and urinary concentrations of retinol-binding protein (U-RBP) ,microalbumine (U-mAlb) were measured respectively .Results Serum levels of Cys C ,hs-CRP ,U-RBP and U-mA1b in all diabetic groups were significantly higher than control group (P< 0 .05) , and worse blood glucose control could lead to higher level of serum Cys C ,hs-CRP ,U-RBP and U-mA1b(P< 0 .05) . Conclusion The higher levels of HbA1c in patients T2DM ,the higher risk of DN .Efficient control of blood glucose level could be important to prevent and postpone the incidence of DN in patients with T 2DM .