CAJ | 학술논문

目的观察福建省慢性丙型肝炎患者基因型分布特点以及与患者性别、年龄、丙型肝炎病毒（HCV） RNA 之间的关系。方法应用反转录聚合酶链反应（RT-PCR）和 SANGER 测序法对155例慢性丙型肝炎患者的HCV 进行基因分型。结果在155例标本中，HCV 基因1型占55．48％，基因2型占18．71％，基因3型13．51％，基因6型12．26％，未见基因4、5型；男女慢性 HCV 感染均以1型为主要基因型，在其他基因型中，男性3型、6型多于2型，女性则以2型为主，差异有统计学意义（P ＜0．05）；基因2型平均年龄为（49岁），3型平均年龄为（35岁），差异有统计学意义（P＜0．05）。结论福建地区 HCV 基因型以1b 型为主，其次是2a 型，未见基因4、5型；基因2型的感染者平均年龄较基因3型大。
목적관찰복건성만성병형간염환자기인형분포특점이급여환자성별、년령、병형간염병독（HCV） RNA 지간적관계。방법응용반전록취합매련반응（RT-PCR）화 SANGER 측서법대155례만성병형간염환자적HCV 진행기인분형。결과재155례표본중，HCV 기인1형점55．48％，기인2형점18．71％，기인3형13．51％，기인6형12．26％，미견기인4、5형；남녀만성 HCV 감염균이1형위주요기인형，재기타기인형중，남성3형、6형다우2형，녀성칙이2형위주，차이유통계학의의（P ＜0．05）；기인2형평균년령위（49세），3형평균년령위（35세），차이유통계학의의（P＜0．05）。결론복건지구 HCV 기인형이1b 형위주，기차시2a 형，미견기인4、5형；기인2형적감염자평균년령교기인3형대。
Objective To study the distribution of hepatitis C virus (HCV) genotypes in patients with chronic hepatitis C (CHC) in Fujian and the relationship with gender ,age and serum HCV RNA level .Methods HCV geno-types were detected 155 CHC patients by using reverse transcript polymerase chain reaction (RT-PCR ) and SANGER sequencing .Results The percentages of HCV genotype 1 ,2 ,3 and 6 were 55 .48% ,18 .71% ,13 .51% and 12 .26% .Genotype 1 was the most common genotype in both male and female CHC patients .Percentages of genotype 3 and 6 were higher than genotype 2 in male patients ,and genotype 2 was more common in female patients ( P <0 .05) .The average age of patients with genotype 2 or 3 were 49 and 35 years old ,with statistical difference between them (P< 0 .05) .Conclusion HCV genotype 1b could be the most common genotype in CHC patients of Fujian ,fol-lowed by genotype 2a ,and the average age of patients with genotype 2 infection might be younger than patients with genotype 3 infection .