CAJ | 학술논문

目的：观察参七脉心通胶囊对颈动脉硬化并高脂血症患者的血脂、血清一氧化氮(NO)、血浆内皮素(ET)水平的影响,进一步探讨参七脉心通胶囊抗动脉粥样硬化的机制。方法将70例高脂血症并颈动脉硬化患者随机分为参七脉心通胶囊中药组(中药组)及阿托伐他汀西药组(西药组),每组35例,分别给予参七脉心通胶囊及阿托伐他汀口服治疗12周。于清晨空腹抽取服药前、服药后及停药2周后的静脉血,检测血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、NO、ET 水平。结果治疗12周后两组患者TC、TG、LDL及 ET明显降低,血清 NO 及 HDL 水平明显升高,与治疗前相比显差异有统计学意义(P<0.01),其中西药组优于治疗组(P<0.05)；停药2周后西药组所有患者 TC、TG和 LDL 水平较治疗后升高,NO 水平明显降低,与服药前无明显差异(P>0.05)；而 ET水平则明显回升,甚至高于服药前水平(P<0.05)。在中药组却未出现这种趋势。结论参七脉心通胶囊对高脂血症并颈动脉硬化患者的血管内皮功能有明显保护作用,从而防治动脉硬化的进一步发展。
목적：관찰삼칠맥심통효낭대경동맥경화병고지혈증환자적혈지、혈청일양화담(NO)、혈장내피소(ET)수평적영향,진일보탐토삼칠맥심통효낭항동맥죽양경화적궤제。방법장70례고지혈증병경동맥경화환자수궤분위삼칠맥심통효낭중약조(중약조)급아탁벌타정서약조(서약조),매조35례,분별급여삼칠맥심통효낭급아탁벌타정구복치료12주。우청신공복추취복약전、복약후급정약2주후적정맥혈,검측혈총담고순(TC)、삼선감유(TG)、고밀도지단백(HDL)、저밀도지단백(LDL)、NO、ET 수평。결과치료12주후량조환자TC、TG、LDL급 ET명현강저,혈청 NO 급 HDL 수평명현승고,여치료전상비현차이유통계학의의(P<0.01),기중서약조우우치료조(P<0.05)；정약2주후서약조소유환자 TC、TG화 LDL 수평교치료후승고,NO 수평명현강저,여복약전무명현차이(P>0.05)；이 ET수평칙명현회승,심지고우복약전수평(P<0.05)。재중약조각미출현저충추세。결론삼칠맥심통효낭대고지혈증병경동맥경화환자적혈관내피공능유명현보호작용,종이방치동맥경화적진일보발전。
Objective To observe the effect of Shenqi Maixintong capsule (SMC)on the lipid,serum nitric oxide (NO),and plas-ma endothelin (ET).Methods Seventy patients with carotid atherosclerosis and hyperlipidemia were randomly divided into two groups:Chinese medicine group (n=35)treated by SMC,and the western medicine group (n=35)treated by atorvastatin orally for 1 2 weeks.The fasting venous blood was collected before and after treatment,2 weeks after the drug withdrawal,to test the level of to-tal cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL),low density lipoprotein cholesterol (LDL),NO, and ET.Results After treatment of 1 2 weeks,the levels of TC,TG,LDL and ET 1 in two groups were decreased significantly,while the level of NO and HDL were increased significantly,there was significant difference compared with before treatment (P<0.01). The effect in western medicine group was better than that in Chinese medicine group (P<0.05).After 2 weeks of withdrawal,the level of TC,TG and LDL in western medicine group was increased compared with that after treatment (P>0.05).The level of NO was decreased significantly,there was no significantly difference compared with that before treatment (P>0.05),and the level of ET was increased and it was higher than that before treatment (P<0.05).Conclusion The SMC had protective effect on vascular endo-thelial in patients with carotid atherosclerosis and hyperlipidemia.It might prevent the further development of atherosclerosis.