中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
18期
2775-2776
,共2页
肺肿瘤%诊断
肺腫瘤%診斷
폐종류%진단
Lung neoplasms%Diagnosis
目的 探讨血清肿瘤标志物联合检测在肺癌诊断中的意义,并选出敏感性最高的血清肿瘤标志物组合.方法 应用酶联免疫吸附法检测62例肺癌患者和62例健康体检者血清中神经元特异性烯醇化酶(NES)、糖链抗原125(CA125)、细胞角蛋白19(CYFRA21-1)及癌胚抗原(CEA)的含量水平.结果 肺癌组患者血清CEA、CA125、CYFRA21-1及NES水平均高于对照组(均P＜0.05)；在4种肿瘤标志物中,CA125的敏感性最高(59.7％),其次为CEA(53.2％)；4种标志物联合检测的敏感性为87.1％,3种标志物联合检测中,以CEA+ CA125+ CYFRA21-1敏感性最高,为85.5％,2种标志物联合检测中CEA+ CA125敏感性最高,为75.8％.结论 4种血清肿瘤标志物对于肺癌的辅助诊断有一定的临床意义,CEA、CA125、CYFRA21-1可作为联合检测肺癌的首选标志物,具有较高的敏感性.
目的 探討血清腫瘤標誌物聯閤檢測在肺癌診斷中的意義,併選齣敏感性最高的血清腫瘤標誌物組閤.方法 應用酶聯免疫吸附法檢測62例肺癌患者和62例健康體檢者血清中神經元特異性烯醇化酶(NES)、糖鏈抗原125(CA125)、細胞角蛋白19(CYFRA21-1)及癌胚抗原(CEA)的含量水平.結果 肺癌組患者血清CEA、CA125、CYFRA21-1及NES水平均高于對照組(均P＜0.05)；在4種腫瘤標誌物中,CA125的敏感性最高(59.7％),其次為CEA(53.2％)；4種標誌物聯閤檢測的敏感性為87.1％,3種標誌物聯閤檢測中,以CEA+ CA125+ CYFRA21-1敏感性最高,為85.5％,2種標誌物聯閤檢測中CEA+ CA125敏感性最高,為75.8％.結論 4種血清腫瘤標誌物對于肺癌的輔助診斷有一定的臨床意義,CEA、CA125、CYFRA21-1可作為聯閤檢測肺癌的首選標誌物,具有較高的敏感性.
목적 탐토혈청종류표지물연합검측재폐암진단중적의의,병선출민감성최고적혈청종류표지물조합.방법 응용매련면역흡부법검측62례폐암환자화62례건강체검자혈청중신경원특이성희순화매(NES)、당련항원125(CA125)、세포각단백19(CYFRA21-1)급암배항원(CEA)적함량수평.결과 폐암조환자혈청CEA、CA125、CYFRA21-1급NES수평균고우대조조(균P＜0.05)；재4충종류표지물중,CA125적민감성최고(59.7％),기차위CEA(53.2％)；4충표지물연합검측적민감성위87.1％,3충표지물연합검측중,이CEA+ CA125+ CYFRA21-1민감성최고,위85.5％,2충표지물연합검측중CEA+ CA125민감성최고,위75.8％.결론 4충혈청종류표지물대우폐암적보조진단유일정적림상의의,CEA、CA125、CYFRA21-1가작위연합검측폐암적수선표지물,구유교고적민감성.
Objective To investigate the significance of combined detection of serum tumor markers in the diagnosis of lung cancer,and to select the most sensitive serum tumor markers.Methods Enzyme-linked immunosorbent assay was used to detect the serum tumor markers of 62 lung cancer patients and 62 healthy persons,who were neuron specific enolase enzyme (NES),carbohydrate antigen 125 (CA 125),cytokeratin 19 (CYFRA21-1) and carcinoembryonic antigen(CEA).Results The level of serum CEA,CA125,CYFRA21-1,and NES of the lung cancer group were all higher than those of the control group (all P ＜ 0.05).Among the four kinds of tumor markers,CA125 had the highest sensitivity(59.7％),which was followed by CEA(53.2％).The sensitivity of the four kinds of joint detection was 87.1％,the highest sensitivity of three markers joint detection was CEA + CA125 + CYFRA21-1 (87.1％),while that of the two kinds of joint detection was CEA + CA125 (75.8％).Conclusion There are high clinical significance in the diagnosis of lung cancer with four kinds of serum tumor markers,CEA + CA125 + CYFRA21-1 can be used as the best markers for joint detection of lung cancer with high sensitivity.
