CAJ | 학술논문

目的：观察高血压性脑出血老年患者血浆脑钠肽（BNP）的动态变化，探讨血浆BNP水平与脑水肿的关系。方法：将56例高血压脑出血老年患者分为手术组（26例）和非手术组（30例），25例老年高血压患者为对照组。在发病后6、24、72、168 h采用酶联免疫吸附试验法定量检测BNP血浆浓度，用无创脑水肿动态监护仪测定脑水肿程度。结果手术组和非手术组血浆BNP含量在6、24、72、168 h高于对照组，差异有统计学意义（P＜0．05），而手术组BNP含量在168 h低于于非手术组；两组患者在24 h开始发生脑水肿，手术组72 h达高峰，非手术组168 h达高峰；血浆BNP水平变化与脑水肿程度呈正相关（r＝0．685，P＜0．05）。结论：动态观察血浆BNP含量是早期诊断和监测高血压性脑出血老年患者急性期脑水肿的有效指标。
목적：관찰고혈압성뇌출혈노년환자혈장뇌납태（BNP）적동태변화，탐토혈장BNP수평여뇌수종적관계。방법：장56례고혈압뇌출혈노년환자분위수술조（26례）화비수술조（30례），25례노년고혈압환자위대조조。재발병후6、24、72、168 h채용매련면역흡부시험법정량검측BNP혈장농도，용무창뇌수종동태감호의측정뇌수종정도。결과수술조화비수술조혈장BNP함량재6、24、72、168 h고우대조조，차이유통계학의의（P＜0．05），이수술조BNP함량재168 h저우우비수술조；량조환자재24 h개시발생뇌수종，수술조72 h체고봉，비수술조168 h체고봉；혈장BNP수평변화여뇌수종정도정정상관（r＝0．685，P＜0．05）。결론：동태관찰혈장BNP함량시조기진단화감측고혈압성뇌출혈노년환자급성기뇌수종적유효지표。
Objective To observe the dynamic change of brain natriuretic peptide (BNP) in plasma of elderly patients with hy-pertensive intracerebral hemorrhage ,and to explore the relationship between BNP levels and cerebral edema .Methods 56 elderly patients with hypertensive intracerebral hemorrhage were recruited and divided into the operation group (n=26) and the non-opera-tion group(n=30) ,25 hypertensive patients were collected as the control group .ELISA was applied to detect the levels of plasma BNP at 6 ,24 ,72 ,168 h after the onset of hypertensive intracerebral hemorrhage .The non-invasion brain edema monitor was utilized to dynamically monitor the cerebral edema degrees .Results The plasma BNP levels in the operation group and the non-operation group at 6 ,24 ,72 ,168 h were higher than those in the control group ,the differences showed statistical difference (P<0 .05) ,but which at 168 h in the operation group was lower than that in the non-operation group ,cerebral edema appeared at 24 h in the two groups ,and reached the peak value at 72 h in the operation group and at68 h in the non-operation group;the changes of plasma BNP levels had positive correlation with cerebral edema degree (r=0 .685 ,P<0 .05) .Conclusion Dynamic monitoring of plasma BNP levels is an effective indicator for early diagnosis and monitoring of acute brain edema in elderly patients with hypertensive in-tracerebral hemorrhage .