CAJ | 학술논문

目的：探讨阿仑膦酸钠及阿法骨化醇联合治疗对2型糖尿病（T2DM ）合并骨质疏松老年女性患者动脉硬化的影响。方法：选取T2DM 合并骨质疏松老年女性28例作为骨质疏松组，T2DM 非骨质疏松老年女性25例作为对照组，给予骨质疏松组阿仑膦酸钠及阿法骨化醇联合治疗12个月，观察股骨颈和ward三角区骨密度（BMD）、T 值、踝臂指数（ABI）、心踝血管指数（CAVI）、颈动脉内膜中层厚度（IM T ）、糖化血红蛋白、血脂、血压的变化。结果与对照组比较，骨质疏松组BMD、T值及ABI明显下降（P＜0．01），而CAVI、IMT明显升高（P＜0．05）。与治疗前比较，骨质疏松组治疗12个月后动脉硬化参数ABI、CAVI及IM T无明显变化，而股骨颈、w ard三角BM D、T 值明显升高（ P＜0．05）；对照组的动脉硬化程度在12个月后较前加重（ P＜0．05），骨密度、T值无明显变化。结论：阿仑膦酸钠联合阿法骨化醇治疗T2DM合并骨质疏松老年女性患者能改善其动脉硬化参数，对其心脑血管疾病的防治有一定作用。
목적：탐토아륜련산납급아법골화순연합치료대2형당뇨병（T2DM ）합병골질소송노년녀성환자동맥경화적영향。방법：선취T2DM 합병골질소송노년녀성28례작위골질소송조，T2DM 비골질소송노년녀성25례작위대조조，급여골질소송조아륜련산납급아법골화순연합치료12개월，관찰고골경화ward삼각구골밀도（BMD）、T 치、과비지수（ABI）、심과혈관지수（CAVI）、경동맥내막중층후도（IM T ）、당화혈홍단백、혈지、혈압적변화。결과여대조조비교，골질소송조BMD、T치급ABI명현하강（P＜0．01），이CAVI、IMT명현승고（P＜0．05）。여치료전비교，골질소송조치료12개월후동맥경화삼수ABI、CAVI급IM T무명현변화，이고골경、w ard삼각BM D、T 치명현승고（ P＜0．05）；대조조적동맥경화정도재12개월후교전가중（ P＜0．05），골밀도、T치무명현변화。결론：아륜련산납연합아법골화순치료T2DM합병골질소송노년녀성환자능개선기동맥경화삼수，대기심뇌혈관질병적방치유일정작용。
Objective To observe the effects of alendronate sodium and alfacalcidol on the parameters of atherosclerosis in old women with type 2 diabetes mellitus(T2DM ) complicating osteoporosis .Methods 28 old women with T2DM complicating osteopo-rosis were taken as the osteoporosis group and 25 old women with T2DM and without osteoporosis were taken as the control group .Alendronate sodium(70 mg/week) and alfacalcidol(0 .5 μg/d) were given to the osteoporosis group for 12 month .The pa-rameters of the bone mass density (BMD)of femoral neck and ,T value ,arkle brachial index (ABI) ,cardio-ankle vascular index (CAVI) and carotid artery intima-media thickness(IMT) ,blood fat and glycosylated hemoglobin were observed .Results Com-pared with the control group ,BMD ,T value and ABI in the osteoporosis group were significantly decreased (P<0 .01) ,while CAVI and IMT were obviously increased(P<0 .05) .Compared with before treatment ABI ,CAVI and IMT after 12 month treatment in the osteoporosis group had no significant changes ,but BMD and T value of femoral neck and ward triangle area were significantly increased(P<0 .05) ,the atherosclerosis degree after 12 months in the control group was significantly aggravated (P<0 .05) .BMD and T value had no obvious change .Conclusion Alendronate sodium combined with alfacalcidol for treating T 2DM complicating os-teoporosis can improve the atherosclerosis parameters and has certain role in preventing and treating cardiovascular and cerebrovas-cular diseases .