CAJ | 학술논문

目的：探讨伊曲康唑在异基因造血干细胞移植患者侵袭性真菌感染预防中的疗效。方法：110例异基因造血干细胞移植患者，预防性应用伊曲康唑或氟康唑，观察两组患者发生侵袭性真菌感染的情况。结果随访至造血干细胞移植后180 d ，伊曲康唑组和氟康唑组侵袭性真菌感染的发生率分别为7．2％（5/69）和19．5％（8/41），二者差异有统计学意义（ P＜0．05）；两组真菌感染相关病死率（2．9％ vs ．7．3％）差异无统计学意义（P＞0．05）；伊曲康唑的不良反应发生率较氟康唑高（26．9％ vs ．7．0％），但患者均能耐受。结论：伊曲康唑预防用药可以显著降低异基因造血干细胞移植患者侵袭性真菌感染的发生率，是一种安全、有效的方法。
목적：탐토이곡강서재이기인조혈간세포이식환자침습성진균감염예방중적료효。방법：110례이기인조혈간세포이식환자，예방성응용이곡강서혹불강서，관찰량조환자발생침습성진균감염적정황。결과수방지조혈간세포이식후180 d ，이곡강서조화불강서조침습성진균감염적발생솔분별위7．2％（5/69）화19．5％（8/41），이자차이유통계학의의（ P＜0．05）；량조진균감염상관병사솔（2．9％ vs ．7．3％）차이무통계학의의（P＞0．05）；이곡강서적불량반응발생솔교불강서고（26．9％ vs ．7．0％），단환자균능내수。결론：이곡강서예방용약가이현저강저이기인조혈간세포이식환자침습성진균감염적발생솔，시일충안전、유효적방법。
Objective To evaluate the clinical effect of itraconazole in prevention of invasive fungal infections in allogeneic hema-topoietic stem cell transplantion .Methods In this retrospective study ,110 patients receiving allogeneic hematopoietic stem cell transplants were administed itraconazole or fluconazole for prevention of fungal infection .The occurrence and prognosis of invasive fungal infection ,and the side effect of both pyrroles were observed .Results Proven and probable invasive fungal infections occurred in 5 of 69 itraconazole recipients(7 .2% ) and in 8 of 41 fluconazole recipients(19 .5% ) during the first 180 days after transplanta-tion ,the difference had statistical significance(P<0 .05) .The fatality rate related to fungal infection had no statistical difference be-tween the two groups(2 .9% vs .7 .3% ) .The occurrence of itraconazole adverse reactions were more than fluconazole (26 .9% vs . 7 .0% ) ,and both itraconazole and fluconazole were well tolerated .Conclusion Itraconazole significantly reduces the incidence of inva-sive fungal infection in the patients receiving allogeneic hematopoietic stem cell transplants ,and it is a effective and safe prophylaxis .