CAJ | 학술논문

目的分析垫江县人民医院2010～2012年鲍曼不动杆菌的耐药性变迁，为临床合理用药并有效控制鲍曼不动杆菌感染提供依据。方法针对该院2010～2012年临床分离的鲍曼不动杆菌耐药情况及患者的感染情况进行回顾性统计分析。结果鲍曼不动杆菌的临床分离率从2010年的218例（12．19％）增高到2012年的741例（18．48％）。18种抗菌药物耐药率基本都在70％以上，重症监护病房、神经科等科室出现泛耐药菌株。抗菌药物的选择性压力是细菌发生耐药性变迁的主要动因之一，年龄、基础疾病、住院时间及侵入性操作等是患者感染的高危因素。结论医院应加强医疗环境、医疗器械及医护人员的消毒，加强医院感染监测，合理使用抗菌药物等一系列措施，可有效控制鲍曼不动杆菌的感染。
목적분석점강현인민의원2010～2012년포만불동간균적내약성변천，위림상합리용약병유효공제포만불동간균감염제공의거。방법침대해원2010～2012년림상분리적포만불동간균내약정황급환자적감염정황진행회고성통계분석。결과포만불동간균적림상분리솔종2010년적218례（12．19％）증고도2012년적741례（18．48％）。18충항균약물내약솔기본도재70％이상，중증감호병방、신경과등과실출현범내약균주。항균약물적선택성압력시세균발생내약성변천적주요동인지일，년령、기출질병、주원시간급침입성조작등시환자감염적고위인소。결론의원응가강의료배경、의료기계급의호인원적소독，가강의원감염감측，합리사용항균약물등일계렬조시，가유효공제포만불동간균적감염。
Objective To analyze the changes of drug resistance of Acinetobacter baumannii in our hospital during 2010-2012 to provide reference for clinical rational drug use and the effective control of Acinetobacter baumannii infection .Methods The drug resistance of Acinetobacter baumannii clinically isolated from 2010 to 2012 and its infection situation were retrospectively performed the statistical analysis .Results The clinical isolation rate of Acinetobacter baumannii in our hospital was increased from 218 cases (12 .19% ) to 741 cases (18 .48% ) in 2012 .The resistance rates of 18 kinds of antibiotics were almost more than 70% ,and pan-drug-resistant Acinetobacter baumannii appeared in some clinical departments ,such as ICU and neurology .The selective pressure of antibiotic was one of the main motive causes of drug resistance change ,and age ,underlying diseases ,duration of hospitalization and invasive procedures were the high risk factors in patients infection .Conclusion Hospital should enhance a series of measures including reinforcing the disinfection of the medical environment ,medical equipments and medical staffs ,strengthening the monito-ring of hospital infection and using antibiotics rationally to reduce and control the prevalence of Acinetobacter baumannii .