CAJ | 학술논문

目的探讨定量检测血清肿瘤标志物糖类抗原125（CA125）、乳酸脱氢酶（LDH）、β2-微球蛋白（β2-MG）及血清铁蛋白（SF）水平在原发性胃淋巴瘤（PGL）中的临床意义。方法回顾分析41例PGL患者血清CA125、LDH、β2-MG、SF水平，比较他们与胃淋巴瘤病理分型、临床分期、分组、国际预后指标（IPI积分）、幽门螺杆菌（Hp）感染的关系。结果 CA125、LDH、β2-MG、SF水平在PGL患者临床分期中ⅢE＋ⅣE期分别较ⅠE＋ⅡE期升高，差异有统计学意义（P＜0．05）；IPI积分中中高危＋高危组较低危＋低中危组明显升高，差异有统计学意义（P＜0．01）。而在病理分型、分组、Hp感染中无明显差异性。结论肿瘤标志物CA125、LDH、β2-MG、SF检测对PGL临床分期及预后判断具有重要的临床价值。
목적탐토정량검측혈청종류표지물당류항원125（CA125）、유산탈경매（LDH）、β2-미구단백（β2-MG）급혈청철단백（SF）수평재원발성위림파류（PGL）중적림상의의。방법회고분석41례PGL환자혈청CA125、LDH、β2-MG、SF수평，비교타문여위림파류병리분형、림상분기、분조、국제예후지표（IPI적분）、유문라간균（Hp）감염적관계。결과 CA125、LDH、β2-MG、SF수평재PGL환자림상분기중ⅢE＋ⅣE기분별교ⅠE＋ⅡE기승고，차이유통계학의의（P＜0．05）；IPI적분중중고위＋고위조교저위＋저중위조명현승고，차이유통계학의의（P＜0．01）。이재병리분형、분조、Hp감염중무명현차이성。결론종류표지물CA125、LDH、β2-MG、SF검측대PGL림상분기급예후판단구유중요적림상개치。
Objective To investigate the clinical significance of quantitatively detecting serum cancer antigen 125(CA125) ,lactate dehydrogenase(LDH) ,β2-microglobulin(β2-MG) and serum ferritin(SF) in primary gastric lymphoma(PGL) .Methods The clini-cal data in 41 cases of PGL confirmed by Pathological examination were retrospectively analyzed on the serum CA 125 ,LDH ,β2-MG and SF levels ,and their relationship with the pathological type ,clinical phase ,grouping ,international prognostic index (IPI) andHe-licobacter pylori infection were compared .Results The serum levels of CA125 ,LDH ,β2-MG and SF in the Ⅲ + Ⅳ stage were high-er than those in the Ⅰ + Ⅱ stage in PGL patients(P<0 .05);the IPI scores in the middle-higher risk + high risk group were obvi-ously higher than those in the lower risk + low-middle risk group (P<0 .01) .There were no significant differences in the patho-logical type ,grouping and Helicobacter pylori infection .Conclusion Detecting the levels of CA125 ,LDH ,β2-MG and SF has the im-portant clinical value to the clinical phase and the prognostic judgment in PGL .