CAJ | 학술논문

目的利用64排螺旋CT灌注成像（CTP）评价丁苯酞软胶囊对急性脑梗死患者的血流动力学的影响。方法选择发病6 h内临床判定为急性大脑半球脑梗死患者，分成试验组与对照组，均行头CT及CTP检查。试验组在常规治疗基础上加用丁苯酞软胶囊0．2 g口服，每6小时服用1次，12 h后均复查CTP。结果试验组治疗后CTP检查提示缺血边缘区脑血容量（CBF）、脑血流量（CBV）较治疗前升高，平均通过时间（MTT）、达峰时间（TTP）较治疗前缩短，与治疗前对照组比较，差异均有统计学意义（P＜0．05）。结论丁苯酞软胶囊能明显改善缺血半暗带的脑血流量，改善缺血区血流灌注。
목적이용64배라선CT관주성상（CTP）평개정분태연효낭대급성뇌경사환자적혈류동역학적영향。방법선택발병6 h내림상판정위급성대뇌반구뇌경사환자，분성시험조여대조조，균행두CT급CTP검사。시험조재상규치료기출상가용정분태연효낭0．2 g구복，매6소시복용1차，12 h후균복사CTP。결과시험조치료후CTP검사제시결혈변연구뇌혈용량（CBF）、뇌혈류량（CBV）교치료전승고，평균통과시간（MTT）、체봉시간（TTP）교치료전축단，여치료전대조조비교，차이균유통계학의의（P＜0．05）。결론정분태연효낭능명현개선결혈반암대적뇌혈류량，개선결혈구혈류관주。
Objective To evaluate the effect of Butylphthalide Soft Capsules on cerebral hemodynamics in patients with acute cerebral infarction by 64 slice spiral CT perfusion(CTP) imaging .Methods The patients with acute cerebral hemisphere infarction within 6 h after the onset were selected and randomly divided into the experimental group and the control group .Conventional plain CT and CTP were performed in both groups .In addition to the routine treatment the experimental group was orally administrated Butylphthalide Soft Capsules 0 .2 g ,once per 6 h .The CTP examination was performed again after 12 h .Results The CTP exami-nation showed that the cerebral perfusion in experimental group was improved in the ischemic marginal region ,the cerebral blood flow(CBF) and cerebral blood volume(CBV) were increased compared with before treatment ,the mean transit time(MTT) and the time to peak( TTP) were shortened compared with the before treatment .Conclusion Butylphthalide Soft Capsules can significantly improve the CBV of ischemic penumbra region and brain ischemic hypoperfusion .