中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2013年
27期
1-2,3
,共3页
血清胱抑素-C%肾功能%慢性阻塞性肺疾病急性加重
血清胱抑素-C%腎功能%慢性阻塞性肺疾病急性加重
혈청광억소-C%신공능%만성조새성폐질병급성가중
Cystatin C%Renal function%AECOPD
目的：探索血清胱抑素-C(Cys-C)与慢性阻塞性肺疾病急性加重(AECOPD)的相关性。方法：回顾性分析2012年5月1日-11月30日收治的笔者所在医院呼吸科所有确诊为AECOPD的住院患者，根据入选标准及排除标准，共54例纳入研究，其中男37例，女17例，平均年龄(66.98±8.07)岁，并随机选择同期处于COPD稳定期患者30例为对照组，男21例，女9例，平均年龄(64.17±10.03)岁，记录两组血清肌酐、尿素氮、Cys-C、肾小球滤过率及住院时间。结果：AECOPD组较对照组Cys-C水平明显高，分别为(1.12±0.26)mg/L、(0.95±0.23)mg/L，差异有统计学意义(P=0.003)。AECOPD组中Cys-C增高患者与Cys-C正常患者尿素氮水平、住院时间分别为(6.98±1.52)mmol/L和(5.21±1.94)mmol/L、(9.13±3.81)d和(7.23±2.41)d，差异有统计学意义(P值分别为0.002和0.033)。AECOPD组Cys-C水平与血尿素氮及住院时间呈正相关，有统计学意义(P<0.05)。结论：Cys-C可反映AECOPD患者早期肾功能损害，是影响AECOPD患者住院时间的一项重要因素。
目的：探索血清胱抑素-C(Cys-C)與慢性阻塞性肺疾病急性加重(AECOPD)的相關性。方法：迴顧性分析2012年5月1日-11月30日收治的筆者所在醫院呼吸科所有確診為AECOPD的住院患者，根據入選標準及排除標準，共54例納入研究，其中男37例，女17例，平均年齡(66.98±8.07)歲，併隨機選擇同期處于COPD穩定期患者30例為對照組，男21例，女9例，平均年齡(64.17±10.03)歲，記錄兩組血清肌酐、尿素氮、Cys-C、腎小毬濾過率及住院時間。結果：AECOPD組較對照組Cys-C水平明顯高，分彆為(1.12±0.26)mg/L、(0.95±0.23)mg/L，差異有統計學意義(P=0.003)。AECOPD組中Cys-C增高患者與Cys-C正常患者尿素氮水平、住院時間分彆為(6.98±1.52)mmol/L和(5.21±1.94)mmol/L、(9.13±3.81)d和(7.23±2.41)d，差異有統計學意義(P值分彆為0.002和0.033)。AECOPD組Cys-C水平與血尿素氮及住院時間呈正相關，有統計學意義(P<0.05)。結論：Cys-C可反映AECOPD患者早期腎功能損害，是影響AECOPD患者住院時間的一項重要因素。
목적：탐색혈청광억소-C(Cys-C)여만성조새성폐질병급성가중(AECOPD)적상관성。방법：회고성분석2012년5월1일-11월30일수치적필자소재의원호흡과소유학진위AECOPD적주원환자，근거입선표준급배제표준，공54례납입연구，기중남37례，녀17례，평균년령(66.98±8.07)세，병수궤선택동기처우COPD은정기환자30례위대조조，남21례，녀9례，평균년령(64.17±10.03)세，기록량조혈청기항、뇨소담、Cys-C、신소구려과솔급주원시간。결과：AECOPD조교대조조Cys-C수평명현고，분별위(1.12±0.26)mg/L、(0.95±0.23)mg/L，차이유통계학의의(P=0.003)。AECOPD조중Cys-C증고환자여Cys-C정상환자뇨소담수평、주원시간분별위(6.98±1.52)mmol/L화(5.21±1.94)mmol/L、(9.13±3.81)d화(7.23±2.41)d，차이유통계학의의(P치분별위0.002화0.033)。AECOPD조Cys-C수평여혈뇨소담급주원시간정정상관，유통계학의의(P<0.05)。결론：Cys-C가반영AECOPD환자조기신공능손해，시영향AECOPD환자주원시간적일항중요인소。
Objective:To discover the relationship between Cys-c and AECOPD.Method:Retrospective analysis of all inpatients with AECOPD in department of respiratory,writer’s hospital during May 1 to November 30,2012.According to the inclusion criteria and exclusion criteria,54 patients with AECOPD confirmed by physical examination were randomly selected as AECOPD group,37 were male and 17 were female.Their average age was (66.98±8.07)years.Meanwhile,30 patients with stable COPD during the same period were selected as control group,21 were male and 9 were female.Their average age was (64.17±10.03)years.Serum creatinine, urea nitrogen,Cys-C,GFR and lengths of stay were recorded for above two groups.Result:Cys-C value of AECOPD group was significantly higher than control group, with (1.12±0.26)mg/L vs (0.95±0.23)mg/L respectively,there was significant difference(P=0.003).In AECOPD group,there were significant difference between Cys-C elevated subgroup and Cys-C normal subgroup for urea nitrogen level and length of stay,with (6.98±1.52)mmol/L vs (5.21±1.94)mmol/L(P=0.002) and (9.13±3.81) vs (7.23±2.41)days(P=0.033).Cys-C shared positive correlations with urea nitrogen and lengths of stay (P<0.05).Conclusion:Cys-C can reflect early renal impairment and is an important factor for affecting lengths of stay in patients with AECOPD.
