CAJ | 학술논문

目的：探讨重症胰腺炎患者应用奥美拉唑联合生长抑素治疗的临床效果。方法：选择2010年1月-2012年12月本院收治的86例重症胰腺炎患者作为观察对象，随机将患者分为观察组和对照组，每组各43例，对照组行常规治疗，观察组在此基础上加用奥美拉唑联合生长抑素，疗程7 d，比较两组患者的临床疗效、各项指标恢复时间和并发症发生情况等。结果：观察组有效率93.0%（40/43），显著高于对照组72.1%（31/43），两组比较差异具有统计学意义（P<0.05）；观察组住院时间、肠道恢复时间、腹痛腹胀缓解时间、血尿淀粉酶、等指标恢复至正常时间及并发症发生率均显著低于对照组，差异具有统计学意义（P<0.05）；观察组死亡率也低于对照组，但差异无统计学意义（P>0.05）。结论：奥美拉唑联合生长抑素治疗重症胰腺炎患者有效率高，症状改善明显，缩短治疗时间，并发症少，死亡率低，值得临床推广应用。
목적：탐토중증이선염환자응용오미랍서연합생장억소치료적림상효과。방법：선택2010년1월-2012년12월본원수치적86례중증이선염환자작위관찰대상，수궤장환자분위관찰조화대조조，매조각43례，대조조행상규치료，관찰조재차기출상가용오미랍서연합생장억소，료정7 d，비교량조환자적림상료효、각항지표회복시간화병발증발생정황등。결과：관찰조유효솔93.0%（40/43），현저고우대조조72.1%（31/43），량조비교차이구유통계학의의（P<0.05）；관찰조주원시간、장도회복시간、복통복창완해시간、혈뇨정분매、등지표회복지정상시간급병발증발생솔균현저저우대조조，차이구유통계학의의（P<0.05）；관찰조사망솔야저우대조조，단차이무통계학의의（P>0.05）。결론：오미랍서연합생장억소치료중증이선염환자유효솔고，증상개선명현，축단치료시간，병발증소，사망솔저，치득림상추엄응용。
Objective:To investigate the clinical effect of omeprazole combined with somatostatin in the treatment of severe acute pancreatitis. Method:Chosed 86 patients with severe acute pancreatitis from January 2010 to December 2012 in our hospital as research object,patients were randomly divided into observation group and control group,43 cases in each group,control group received routine therapy,observation group based on control group,combined omeprazole with somatostatin,treatment period was 7 days,the clinical curative effects,recovery time and complications were compared between two groups. Result:The effective rate in observation group was 93.0%(40/43),significantly higher than 72.1%(31/43)in control group,had statistically significant differences between two groups(P<0.05);hospitalization time,intestinal recovery time,abdominal pain relief time, blood amylase,urine amylase were restored to normal time and the incidence of complications in observation group were significantly lower than that of control group,the difference was significant(P<0.05);and the mortality in observation group was significantly lower than those in control group,but the differences had no statistically significant(P>0.05). Conclusion:Omeprazole combined with somatostatin in the treatment of severe acute pancreatitis patients with high effective rate,symptoms improved significantly,shorten treatment time,less complications,low mortality,it is worthy of clinical application.