中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
28期
8-10
,共3页
去氧氟尿苷%局部晚期鼻咽癌%同步放化疗
去氧氟尿苷%跼部晚期鼻嚥癌%同步放化療
거양불뇨감%국부만기비인암%동보방화료
Doxifluridine%Locally advanced nasopharyngeal carcinoma%Concurrent chemoradiotherapy
目的：探讨去氧氟尿苷单药用于局部晚期鼻咽癌同步放化疗的有效性和安全性。方法：90例局部晚期鼻咽癌患者，随机分为去氧氟尿苷单药组、PF方案组和单纯放疗组，每组各30例。去氧氟尿苷单药组接受去氧氟尿苷单药同步放化疗（去氧氟尿苷胶囊口服，每日剂量0.8~1.2 g，分3次口服，从放疗开始当日至放疗结束当日）；单纯放疗组接受单纯放疗；PF方案组接受PF方案同步放化疗（5-Fu 500 mg/m2静滴dl-5，DDP 80 mg/m2静滴d1，21 d为1周期）。观察各组疗效及不良反应。结果：去氧氟尿苷单药组与PF方案组疗效相当，均优于单独放疗组。在不良反应方面，去氧氟尿苷单药组的恶心呕吐、口腔黏膜炎、白细胞减少等不良反应的发生率均低于PF方案组，比较差异均有统计学意义（P<0.05）。结论：去氧氟尿苷单药用于局部晚期鼻咽癌同步放化疗疗效好，不良反应轻，患者耐受性好。
目的：探討去氧氟尿苷單藥用于跼部晚期鼻嚥癌同步放化療的有效性和安全性。方法：90例跼部晚期鼻嚥癌患者，隨機分為去氧氟尿苷單藥組、PF方案組和單純放療組，每組各30例。去氧氟尿苷單藥組接受去氧氟尿苷單藥同步放化療（去氧氟尿苷膠囊口服，每日劑量0.8~1.2 g，分3次口服，從放療開始噹日至放療結束噹日）；單純放療組接受單純放療；PF方案組接受PF方案同步放化療（5-Fu 500 mg/m2靜滴dl-5，DDP 80 mg/m2靜滴d1，21 d為1週期）。觀察各組療效及不良反應。結果：去氧氟尿苷單藥組與PF方案組療效相噹，均優于單獨放療組。在不良反應方麵，去氧氟尿苷單藥組的噁心嘔吐、口腔黏膜炎、白細胞減少等不良反應的髮生率均低于PF方案組，比較差異均有統計學意義（P<0.05）。結論：去氧氟尿苷單藥用于跼部晚期鼻嚥癌同步放化療療效好，不良反應輕，患者耐受性好。
목적：탐토거양불뇨감단약용우국부만기비인암동보방화료적유효성화안전성。방법：90례국부만기비인암환자，수궤분위거양불뇨감단약조、PF방안조화단순방료조，매조각30례。거양불뇨감단약조접수거양불뇨감단약동보방화료（거양불뇨감효낭구복，매일제량0.8~1.2 g，분3차구복，종방료개시당일지방료결속당일）；단순방료조접수단순방료；PF방안조접수PF방안동보방화료（5-Fu 500 mg/m2정적dl-5，DDP 80 mg/m2정적d1，21 d위1주기）。관찰각조료효급불량반응。결과：거양불뇨감단약조여PF방안조료효상당，균우우단독방료조。재불량반응방면，거양불뇨감단약조적악심구토、구강점막염、백세포감소등불량반응적발생솔균저우PF방안조，비교차이균유통계학의의（P<0.05）。결론：거양불뇨감단약용우국부만기비인암동보방화료료효호，불량반응경，환자내수성호。
Objective:To investigate the effect and safety of doxifluridine combined with concurrent radiotherapy for locally advanced nasopharyngeal carcinoma.Method:Total of 90 patients with locally advanced nasopharyngeal carcinoma were randomly divided into the doxifluridine single drug group,the PF regimen group and the simple radiotherapy group,30 cases in each group.The doxifluridine single drug group was given chemotherapy of single doxifluridine(doxifluridine capsule 0.8-1.2 g/d PO,from the first day to the last day of radiotherapy)with concurrent radiotherapy. The simple radiotherapy group was given single radiotherapy.The PF regimen group was given chemotherapy of PF regimen jointing concurrent radiotherapy (5-FU 500mg/m2 iv d1-d5,cisplatin 80 mg/m2 iv d1;21days was a cycle).The therapeutic effect and side effect of all groups were evaluated.Result:The effect of doxifluridine single drug group was similar to that of the PF regimen group and better than that of single radiotherapy group.The incidence of nausea/vomiting,oral mucositis and leucopenia in simple radiotherapy group were lower than that in PF regimen group.Conclusion:Chemotherapy of single doxifluridine with concurrent radiotherapy is an effective and well-tolerated regimen for the treatment of locally advanced nasopharyngeal carcinoma.
